IL36G

Gene Symbol	IL36G
Entrez Gene	56300
Alt Symbol	IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2
Species	Human
Gene Type	protein-coding
Description	interleukin 36, gamma
Other Description	IL-1 epsilon\|IL-1 related protein 2\|IL-1(EPSILON)\|IL-1-epsilon\|IL-1-related protein 2\|interleukin 1 family, member 9\|interleukin 1-related protein 2\|interleukin-1 epsilon\|interleukin-1 family member 9\|interleukin-1 homolog 1\|interleukin-36 gamma
Swissprots	Q6UVX7 Q9NZH8 Q56B91 Q7RTZ9
Accessions	AAX59035 AAY14987 CAD29874 EAW73613 Q9NZH8 AF200492 AAF69248 AF206696 AAG35670 AY359111 AAQ89469 BC096721 AAH96721 BC098130 AAH98130 BC098155 AAH98155 BC098337 AAH98337 XM_011511498 XP_011509800 NM_001278568 NP_001265497 NM_019618 NP_062564
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat
Subcellular Location	Secreted {ECO:0000269\|PubMed:20870894}.
Tissue Specificity	Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages. {ECO:0000269\|PubMed:20870894, ECO:0000269\|PubMed:23095752}.

IL-1F9 (A-13) - sc-168161 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

IL-1F9 (Y-12) - sc-80056 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rat
Clonality	Monoclonal

Anti-IL36 gamma antibody - ab116281 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL36 gamma antibody (ab116281) at 1 µg/ml + Tonsil (Human) Tissue Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL36 gamma antibody - ab96191 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IL36 gamma antibody (ab96191) at 1/500 dilutionLane 1 : H1299 whole cell lysateLane 2 : HeLa S3 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-IL36 gamma antibody - ab57627 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57627 IL1F9 antibody at 1ug/ml.

Anti-IL36 gamma antibody [2F4] - ab156783 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F4

All lanes : Anti-IL36 gamma antibody [2F4] (ab156783) at 1/4000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY IL36 gamma cDNALysates/proteins at 5 µg per lane.

Anti-IL36 gamma antibody [6E4] - ab140968 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6E4

All lanes : Anti-IL36 gamma antibody [6E4] (ab140968) at 1/4000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY IL36 gamma cDNALysates/proteins at 5 µg per lane.

Anti-IL36 gamma antibody - C-terminal - ab180903 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1 : Anti-IL36 gamma antibody - C-terminal (ab180903) at 1 µg/mlLane 2 : Anti-IL36 gamma antibody - C-terminal (ab180903) at 2 µg/mlLane 1 : Human spleen tissue lysateLane 2 : Human spleen tissue lysateLysates/proteins at 15 µg per lane.

Anti-IL1F9 Antibody (C-Terminus) - LS-C201142 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of IL-36G in human bladder tissue with IL-36G antibody at 5 ug/ml.

Anti-IL1F9 Antibody (clone 6E4) - LS-C174631 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6E4

IHC of paraffin-embedded Human pancreas tissue using anti-IL1F9 mouse monoclonal antibody.

Anti-IL1F9 Antibody (clone 2F4) - LS-C338023 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F4

IHC of paraffin-embedded Human pancreas tissue using anti-IL1F9 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-IL1F9 Antibody (aa1-162) - LS-C294786 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (aa1-162, Biotin) - LS-C297380 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (aa5-149, Biotin) - LS-C297381 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (aa1-162, FITC) - LS-C301599 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (aa5-149, FITC) - LS-C301601 from LifeSpan Bioscience

Prices	$495.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (clone 2A8) - LS-C139453 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2A8

Detection limit for recombinant GST tagged IL1F9 is 0.03 ng/ml as a capture antibody.

Anti-IL1F9 Antibody (aa5-149) - LS-C294790 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IL1F9 Antibody (aa5-149) - LS-C314326 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-IL1F9 Antibody (aa105-169) - LS-C185990 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded HeLa xenograft using IL1F9 antibody antibody at 1:500 dilution.

IL-36 gamma/IL-1F9 Antibody [Unconjugated] - AF2320 from Novus Biologicals

Prices	$99.00, $365.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

Western blot shows lysates of A431 human epithelial carcinoma cell line untreated (-) or treated (+) with 20 ng/mL Recombinant Human IFN‑ gamma (Catalog # 285‑IF) and 20 ng/mL Recombinant Human TNF‑ alpha (Catalog # 210‑TA) for 6 hours. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human IL‑36 gamma /IL‑1F9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2320) followed by HRP‑conjugated Anti‑Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for IL‑36 gamma /IL‑1F9 at approximately 18 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

IL-36 gamma/IL-1F9 Antibody (278706) - MAB2320 from Novus Biologicals

Prices	$99.00, $269.00, $699.00
Sizes	25 µg, 100 µg, 500 µg
Host	Rat
Clonality	Monoclonal
Clone	278706

IL1F9 Antibody - NBP1-31185 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: IL1F9 Antibody [NBP1-31185] - Sample(30 ug of whole cell lysate) A:H1299 B:HeLa S312% SDS PAGE diluted at 1:500

IL1F9 Antibody (8A11) - H00056300-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	8A11

Sandwich ELISA: IL1F9 Antibody (8A11) [H00056300-M01] - Detection limit for recombinant GST tagged IL1F9 is approximately 0.03ng/ml as a capture antibody.

IL1F9 Antibody (MM0388-2P38) - NBP2-11688 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal
Clone	MM0388-2P38

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