IL36G

Gene Symbol	IL36G
Entrez Gene	56300
Alt Symbol	IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2
Species	Human
Gene Type	protein-coding
Description	interleukin 36, gamma
Other Description	IL-1 epsilon|IL-1 related protein 2|IL-1(EPSILON)|IL-1-epsilon|IL-1-related protein 2|interleukin 1 family, member 9|interleukin 1-related protein 2|interleukin-1 epsilon|interleukin-1 family member 9|interleukin-1 homolog 1|interleukin-36 gamma
Swissprots	Q6UVX7 Q9NZH8 Q56B91 Q7RTZ9
Accessions	AAX59035 AAY14987 CAD29874 EAW73613 Q9NZH8 AF200492 AAF69248 AF206696 AAG35670 AY359111 AAQ89469 BC096721 AAH96721 BC098130 AAH98130 BC098155 AAH98155 BC098337 AAH98337 XM_011511498 XP_011509800 NM_001278568 NP_001265497 NM_019618 NP_062564
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat
Subcellular Location	Secreted {ECO:0000269|PubMed:20870894}.
Tissue Specificity	Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages. {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-IL1F9-cDNA-Clone - DC09123 from Abgent, a WuXi AppTec company Prices $228.15 Sizes 10 µg Species Human Accession NM_019618

Human IL1F9 ORF Clone(NM_019618.2) - CDCL167101 from Creative Biomart Species Human Accession NM_019618.2

Human IL1F9 ORF clone(NM_019618.2) - CDCL184818 from Creative Biomart Species Human Accession NM_019618.2

Human IL36G cDNA clone(NM_019618.2) - CDFG002343 from Creative Biomart Species Human Accession NM_019618.2

Human Il36g ORF clone(NM_019618.2) - CDCH387043 from Creative Biomart Species Human Accession NM_019618.2

Human IL36G ORF Clone(NM_019618.2) - CDCR304755 from Creative Biomart Species Human Accession NM_019618.2

Human IL36G ORF Clone(NM_019618.2) - CDCR304756 from Creative Biomart Species Human Accession NM_019618.2

Human IL36G ORF Clone(NM_019618.2) - CDCR304757 from Creative Biomart Species Human Accession NM_019618.2

Human IL36G Gene ORF cDNA clone in cloning vector - HG10124-M from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, N-His tag - HG10124-NH from Sino Biological Species Human

Human IL36G / IL1F9 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10124-M-F from Sino Biological Species Human Accession NM_019618.2

Human IL36G Gene ORF cDNA clone expression plasmid, C-His tag - HG10124-M-H from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid - HG10124-UT from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-HA tag - HG10124-CY from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-His tag - HG10124-CH from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10124-NF from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10124-CF from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, N-HA tag - HG10124-NY from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10124-NM from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10124-ACG from Sino Biological Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10124-CM from Sino Biological Species Human

Human IL1F9 ORF clone(NM_019618.2) - CDCL184818 from Creative biogene Species Human

Human IL36G ORF Clone (BC098337) - CDCS418776 from Creative biogene Species Human Accession Q9NZH8

Human IL36G cDNA Clone(NM_019618.2) - CDFG002343 from Creative biogene Species Human

Human IL36G Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10124-ACR from Sino Biological Species Human

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