IL36G
| Gene Symbol | IL36G |
|---|---|
| Entrez Gene | 56300 |
| Alt Symbol | IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 36, gamma |
| Other Description | IL-1 epsilon|IL-1 related protein 2|IL-1(EPSILON)|IL-1-epsilon|IL-1-related protein 2|interleukin 1 family, member 9|interleukin 1-related protein 2|interleukin-1 epsilon|interleukin-1 family member 9|interleukin-1 homolog 1|interleukin-36 gamma |
| Swissprots | Q6UVX7 Q9NZH8 Q56B91 Q7RTZ9 |
| Accessions | AAX59035 AAY14987 CAD29874 EAW73613 Q9NZH8 AF200492 AAF69248 AF206696 AAG35670 AY359111 AAQ89469 BC096721 AAH96721 BC098130 AAH98130 BC098155 AAH98155 BC098337 AAH98337 XM_011511498 XP_011509800 NM_001278568 NP_001265497 NM_019618 NP_062564 |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat |
| Subcellular Location | Secreted {ECO:0000269|PubMed:20870894}. |
| Tissue Specificity | Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up- regulated in lesional psoriasis skin. Expressed in monocyte- derived dendritic cells and M1 macrophages. {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}. |
IL-1F9 CRISPR/Cas9 KO Plasmid (h) - sc-406176 from Santa Cruz Biotechnology
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IL-1F9 HDR Plasmid (h) - sc-406176-HDR from Santa Cruz Biotechnology
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IL-1F9 Double Nickase Plasmid (h) - sc-406176-NIC from Santa Cruz Biotechnology
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IL-1F9 Double Nickase Plasmid (h2) - sc-406176-NIC-2 from Santa Cruz Biotechnology
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IL-1F9 CRISPR Activation Plasmid (h) - sc-406176-ACT from Santa Cruz Biotechnology
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IL-1F9 CRISPR Activation Plasmid (h2) - sc-406176-ACT-2 from Santa Cruz Biotechnology
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IL-1F9 Lentiviral Activation Particles (h) - sc-406176-LAC from Santa Cruz Biotechnology
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IL-1F9 Lentiviral Activation Particles (h2) - sc-406176-LAC-2 from Santa Cruz Biotechnology
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IL-1F9 siRNA (h) - sc-72176 from Santa Cruz Biotechnology
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IL-1F9 shRNA Plasmid (h) - sc-72176-SH from Santa Cruz Biotechnology
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IL-1F9 shRNA (h) Lentiviral Particles - sc-72176-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10595 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10595 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05594 from Sigma-Aldrich
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IL36G siRNA (Human) - CRJ1132 from Cohesion Biosciences
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IL1F9 RNAi - H00056300-R01 from Novus Biologicals
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IL36G - MBS8210569 from MyBioSource
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IL-1F9 CRISPR/Cas9 KO Plasmid (h2) - sc-406176-KO-2 from Santa Cruz Biotechnology
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IL-1F9 HDR Plasmid (h2) - sc-406176-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Il36g (NM_019618.2) - SHH318957 from Creative biogene
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shRNA set against Human IL1F9(NM_019618.2) - SHL172488 from Creative biogene
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Human IL36G siRNA - orb271633 from Biorbyt
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IL36G shRNA Plasmid (Human) - CHJ1132 from Cohesion Biosciences
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IL36G miRNA 3'UTR clone - MiUTR1H-04896 from Creative biogene
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