NR1H4

Gene Symbol NR1H4
Entrez Gene 9971
Alt Symbol BAR, FXR, HRR-1, HRR1, RIP14
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 1, group H, member 4
Other Description RXR-interacting protein 14|bile acid receptor|farnesoid X nuclear receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14
Swissprots A1L4K5 Q8NFP5 F8VYG8 B7ZM06 Q92943 Q8NFP6 B7Z412 Q96RI1
Accessions EAW97638 EAW97639 EAW97640 Q96RI1 AB307699 BAH02290 AF384555 AAK60271 AF478445 AAM53550 AF478446 AAM53551 AK296612 BAH12398 AK296647 BAH12409 AK312959 BAG35798 BC035654 BC071778 AAH71778 BC130573 AAI30574 BC144183 BC144184 AAI44185 BC144187 BX571749 CAE11874 DA011411 HQ709175 ADZ17382 U68233 AAB08107 XM_006719719 XP_006719782 XM_011539040 XP_011537342 XM_011539041 XP_011537343 XM_011539042 XP_011537344 XR_245969 NM_001206977 NP_001193906 NM_001206978 NP_001193907 NM_001206979 NP_001193908 NM_001206992 NP_001193921 NM_001206993 NP_001193922 NM_005123 NP_005114
Function Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769}.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Bile secretion

FXR (Q-20) - sc-1205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FXR (Q-20): sc-1205. Western blot analysis of FXR expression in HeLa nuclear extract.

FXR (H-130) - sc-13063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FXR (H-130): sc-13063. Western blot analysis of human recombinant FXR fusion protein.

FXR (D-3) - sc-25309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FXR (D-3): sc-25309. Western blot analysis of human recombinant FXR fusion protein (A,B).

FXR (C-20) - sc-1204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FXR (C-20): sc-1204. Western blot analysis of FXR expression in Hep G2 whole cell lysate.

Anti-Bile Acid Receptor NR1H4 antibody - ab85606 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bile Acid Receptor NR1H4 antibody (ab85606) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 3 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Bile Acid Receptor NR1H4 antibody - ab28480 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Bile Acid Receptor NR1H4 antibody - ab58559 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Bile Acid Receptor NR1H4 antibody (ab58559) at 1 µg/ml + Human Lung lysate (35ug protein in RIPA buffer).

Anti-Bile Acid Receptor NR1H4 antibody - ab86025 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bile Acid Receptor NR1H4 antibody (ab86025) at 1/1000 dilutionLane 1 : An un-induced culture of E. coliLane 2 : An induced culture of E. coliLysates/proteins at 1/5000 dilution per lane.SecondaryAnti-Rabbit IgG HRP at 1/1000 dilution

Anti-Bile Acid Receptor NR1H4 antibody - ab56902 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Bile Acid Receptor NR1H4 antibody [322.1.2.2] - N-terminal - ab187735 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 322.1.2.2
All lanes : Anti-Bile Acid Receptor NR1H4 antibody [322.1.2.2] - N-terminal (ab187735) at 8 µg/mlLane 1 : Alexander cell lysateLane 2 : Alexander cell lysate transfected with Bile Acid Receptor NR1H4SecondaryHRP-labeled goat anti-mouse IgG at 1/2000 dilutiondeveloped using the ECL technique

Anti-Bile Acid Receptor NR1H4 antibody [EPR5721] - ab126602 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5721
All lanes : Anti-Bile Acid Receptor NR1H4 antibody [EPR5721] (ab126602) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-NR1H4 / FXR Antibody (aa2-126) - LS-C6986 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NR1H4 / FXR Antibody (C-Terminus) - LS-C66389 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (C-Terminus, Biotin) - LS-C142216 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (C-Terminus, DY650) - LS-C142217 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (C-Terminus) - LS-C2784 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.

Anti-NR1H4 / FXR Antibody (C-Terminus, DY488) - LS-C142218 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (C-Terminus, HRP) - LS-C142219 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (C-Terminus, DY550) - LS-C142220 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (aa446-476) - LS-C190815 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (aa446-476, Rhodamine) - LS-C183858 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (aa446-476, Biotin) - LS-C190816 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (aa323-372) - LS-C107782 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR1H4 antibody LS-C107782 Western blot of THP-1 cell lysate.

Anti-NR1H4 / FXR Antibody - LS-C136933 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR1H4 / FXR Antibody (aa33-82) - LS-C205753 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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