NR1H4

Gene Symbol	NR1H4
Entrez Gene	9971
Alt Symbol	BAR, FXR, HRR-1, HRR1, RIP14
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group H, member 4
Other Description	RXR-interacting protein 14|bile acid receptor|farnesoid X nuclear receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14
Swissprots	A1L4K5 Q8NFP5 F8VYG8 B7ZM06 Q92943 Q8NFP6 B7Z412 Q96RI1
Accessions	EAW97638 EAW97639 EAW97640 Q96RI1 AB307699 BAH02290 AF384555 AAK60271 AF478445 AAM53550 AF478446 AAM53551 AK296612 BAH12398 AK296647 BAH12409 AK312959 BAG35798 BC035654 BC071778 AAH71778 BC130573 AAI30574 BC144183 BC144184 AAI44185 BC144187 BX571749 CAE11874 DA011411 HQ709175 ADZ17382 U68233 AAB08107 XM_006719719 XP_006719782 XM_011539040 XP_011537342 XM_011539041 XP_011537343 XM_011539042 XP_011537344 XR_245969 NM_001206977 NP_001193906 NM_001206978 NP_001193907 NM_001206979 NP_001193908 NM_001206992 NP_001193921 NM_001206993 NP_001193922 NM_005123 NP_005114
Function	Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769}.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Bile Acid Receptor NR1H4 full length protein - ab81918 from Abcam Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

Human Bile Acid Receptor NR1H4 full length protein - ab81889 from Abcam Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

Human Bile Acid Receptor NR1H4 peptide - ab97929 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Bile Acid Receptor NR1H4 protein fragment - ab81842 from Abcam Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

Human Bile Acid Receptor NR1H4 protein fragment - ab81946 from Abcam Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

Mouse Bile Acid Receptor NR1H4 peptide - ab39820 from Abcam Category Peptide Species Mouse

BAR / BFAR Antibody Blocking Peptide - LS-E4409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAR / BFAR Antibody Blocking Peptide - LS-E30857 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BAR / BFAR Antibody Blocking Peptide - LS-E15904 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1H4 / FXR Antibody Blocking Peptide - LS-E6313 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1H4 / FXR Antibody Blocking Peptide - LS-E11908 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1H4 / FXR Antibody Blocking Peptide - LS-E26223 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1H4 / FXR Antibody Blocking Peptide - LS-E16656 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FXR/NR1H4 Blocking Peptide - NB400-153PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human FXR/NR1H4 Protein - H00009971-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NR1H4-Antibody-N-term-Blocking-Peptide - BP19002a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BFAR Peptide - GTX85010-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

NR1H4 blocking peptide - GTX89181-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Human NR1H4 protein - orb244897 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

E.coli bar protein - orb244673 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

Goat anti NR1H4 antibody Immunizing peptide - orb50225 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

NR1H4 Blocking Peptide - 33R-8322 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Bile Acid Receptor Nr1H4 Peptide - AC21-1054-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NR1H4 / FXR - H00009971-P01 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

NR1H4 / FXR - H00009971-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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