| Gene Symbol |
NR1H4
|
| Entrez Gene |
9971
|
| Alt Symbol |
BAR, FXR, HRR-1, HRR1, RIP14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 1, group H, member 4
|
| Other Description |
RXR-interacting protein 14|bile acid receptor|farnesoid X nuclear receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14
|
| Swissprots |
A1L4K5 Q8NFP5 F8VYG8 B7ZM06 Q92943 Q8NFP6 B7Z412 Q96RI1
|
| Accessions |
EAW97638 EAW97639 EAW97640 Q96RI1 AB307699 BAH02290 AF384555 AAK60271 AF478445 AAM53550 AF478446 AAM53551 AK296612 BAH12398 AK296647 BAH12409 AK312959 BAG35798 BC035654 BC071778 AAH71778 BC130573 AAI30574 BC144183 BC144184 AAI44185 BC144187 BX571749 CAE11874 DA011411 HQ709175 ADZ17382 U68233 AAB08107 XM_006719719 XP_006719782 XM_011539040 XP_011537342 XM_011539041 XP_011537343 XM_011539042 XP_011537344 XR_245969 NM_001206977 NP_001193906 NM_001206978 NP_001193907 NM_001206979 NP_001193908 NM_001206992 NP_001193921 NM_001206993 NP_001193922 NM_005123 NP_005114
|
| Function |
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Bile secretion
|