NR1H4
| Gene Symbol | NR1H4 |
|---|---|
| Entrez Gene | 9971 |
| Alt Symbol | BAR, FXR, HRR-1, HRR1, RIP14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 1, group H, member 4 |
| Other Description | RXR-interacting protein 14|bile acid receptor|farnesoid X nuclear receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14 |
| Swissprots | A1L4K5 Q8NFP5 F8VYG8 B7ZM06 Q92943 Q8NFP6 B7Z412 Q96RI1 |
| Accessions | EAW97638 EAW97639 EAW97640 Q96RI1 AB307699 BAH02290 AF384555 AAK60271 AF478445 AAM53550 AF478446 AAM53551 AK296612 BAH12398 AK296647 BAH12409 AK312959 BAG35798 BC035654 BC071778 AAH71778 BC130573 AAI30574 BC144183 BC144184 AAI44185 BC144187 BX571749 CAE11874 DA011411 HQ709175 ADZ17382 U68233 AAB08107 XM_006719719 XP_006719782 XM_011539040 XP_011537342 XM_011539041 XP_011537343 XM_011539042 XP_011537344 XR_245969 NM_001206977 NP_001193906 NM_001206978 NP_001193907 NM_001206979 NP_001193908 NM_001206992 NP_001193921 NM_001206993 NP_001193922 NM_005123 NP_005114 |
| Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO:0000269|PubMed:10334992, ECO:0000269|PubMed:10334993, ECO:0000269|PubMed:12718892, ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:15471871, ECO:0000269|PubMed:18621523, ECO:0000269|PubMed:19410460, ECO:0000269|PubMed:19586769}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Top Pathways | Bile secretion |
FXR CRISPR/Cas9 KO Plasmid (h) - sc-417410 from Santa Cruz Biotechnology
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FXR HDR Plasmid (h) - sc-417410-HDR from Santa Cruz Biotechnology
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FXR Double Nickase Plasmid (h) - sc-417410-NIC from Santa Cruz Biotechnology
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FXR Double Nickase Plasmid (h2) - sc-417410-NIC-2 from Santa Cruz Biotechnology
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FXR CRISPR Activation Plasmid (h) - sc-417410-ACT from Santa Cruz Biotechnology
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FXR CRISPR Activation Plasmid (h2) - sc-417410-ACT-2 from Santa Cruz Biotechnology
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FXR Lentiviral Activation Particles (h) - sc-417410-LAC from Santa Cruz Biotechnology
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FXR Lentiviral Activation Particles (h2) - sc-417410-LAC-2 from Santa Cruz Biotechnology
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FXR siRNA (h) - sc-38848 from Santa Cruz Biotechnology
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FXR shRNA Plasmid (h) - sc-38848-SH from Santa Cruz Biotechnology
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FXR shRNA (h) Lentiviral Particles - sc-38848-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU133161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15488 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15488 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03306 from Sigma-Aldrich
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NR1H4 siRNA (Human) - CRH6708 from Cohesion Biosciences
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FXR/NR1H4 RNAi - H00009971-R01 from Novus Biologicals
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shRNA set against Human NR1H4 (NM_005123.3) - SHH354684 from Creative biogene
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shRNA set against Human NR1H4(NM_001206978.1) - SHR019896 from Creative biogene
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shRNA set against Human NR1H4(NM_001206993.1) - SHR019914 from Creative biogene
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shRNA set against Human NR1H4(NM_001206977.1) - SHR019932 from Creative biogene
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shRNA set against Human NR1H4(NM_001206992.1) - SHR020004 from Creative biogene
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Human NR1H4 siRNA - orb267210 from Biorbyt
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NR1H4 shRNA Plasmid (Human) - CHH6708 from Cohesion Biosciences
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NR1H4 miRNA 3'UTR clone - MiUTR1H-06894 from Creative biogene
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