PIAS1

Gene Symbol	PIAS1
Entrez Gene	8554
Alt Symbol	DDXBP1, GBP, GU/RH-II, ZMIZ3
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 1
Other Description	AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
Swissprots	Q9UN02 B3KSY9 Q147X4 C5J4B4 B2RB67 O75925 Q99751
Accessions	EAW77804 EAW77805 O75925 AF077951 AAC36702 AF167160 AAD49722 AK094641 BAG52901 AK314515 BAG37114 AY826819 AAX18639 BC053685 BC104646 BC118587 AAI18588 BC121797 AAI21798 EF487997 ABP49565 EF487998 ABP49566 FJ997900 ACR77525 U78524 AAB58488 XM_005254735 XP_005254792 XM_011522126 XP_011520428 XM_011522127 XP_011520429 XM_011522128 XP_011520430 NM_016166 NP_057250
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269|PubMed:1
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Tissue Specificity	Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PIAS1 (D33A7) XP ® Rabbit mAb - 3550 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D33A7

PIAS 1 (F-1) - sc-365127 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PIAS 1 (H-175) - sc-14016 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PIAS 1 (C-20) - sc-8152 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIAS 1/3 (F-3) - sc-271172 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PIAS 1/3 (N-18) - sc-8153 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PIAS1 antibody - ab58403 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 antibody - ab172123 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PIAS1 antibody [EPR2580(2)] - ab109388 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2580(2)

Anti-PIAS1 antibody - C-terminal - ab187751 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (aa636-651) - LS-C313346 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (C-Terminus) IHC-plus™ - LS-B4649 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus, FITC) - LS-C220359 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus, Azide-free, HRP) - LS-C220360 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus, PE) - LS-C220362 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus) - LS-C328231 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus) - LS-C328235 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (Internal, clone EPR2580(2)) IHC-plus™ - LS-B9173 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EPR2580(2)

Anti-PIAS1 Antibody (Gly24) - LS-C176341 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (aa100-130) - LS-C98792 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (aa409-645) - LS-C296103 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody - LS-C346096 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (C-Terminus) - LS-C110360 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (N-Terminus) - LS-C110359 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIAS1 Antibody (C-Terminus, AP) - LS-C220349 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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