PIAS1

Gene Symbol	PIAS1
Entrez Gene	8554
Alt Symbol	DDXBP1, GBP, GU/RH-II, ZMIZ3
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 1
Other Description	AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
Swissprots	Q9UN02 B3KSY9 Q147X4 C5J4B4 B2RB67 O75925 Q99751
Accessions	EAW77804 EAW77805 O75925 AF077951 AAC36702 AF167160 AAD49722 AK094641 BAG52901 AK314515 BAG37114 AY826819 AAX18639 BC053685 BC104646 BC118587 AAI18588 BC121797 AAI21798 EF487997 ABP49565 EF487998 ABP49566 FJ997900 ACR77525 U78524 AAB58488 XM_005254735 XP_005254792 XM_011522126 XP_011520428 XM_011522127 XP_011520429 XM_011522128 XP_011520430 NM_016166 NP_057250
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269|PubMed:1
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Tissue Specificity	Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PIAS 1 CRISPR/Cas9 KO Plasmid (h) - sc-402407 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 HDR Plasmid (h) - sc-402407-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 Double Nickase Plasmid (h) - sc-402407-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 Double Nickase Plasmid (h2) - sc-402407-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 CRISPR Activation Plasmid (h) - sc-402407-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 CRISPR Activation Plasmid (h2) - sc-402407-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 Lentiviral Activation Particles (h) - sc-402407-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 Lentiviral Activation Particles (h2) - sc-402407-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PIAS 1 siRNA (h) - sc-36219 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS 1 shRNA Plasmid (h) - sc-36219-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS 1 shRNA (h) Lentiviral Particles - sc-36219-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS 1/3 siRNA (h) - sc-44013 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS 1/3 shRNA Plasmid (h) - sc-44013-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS 1/3 shRNA (h) Lentiviral Particles - sc-44013-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PIAS1 RNAi - H00008554-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU129441 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16773 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16773 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01451 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01451

PIAS1 siRNA (Human) - CRH5623 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PIAS1(NM_016166.1) - SHR113106 from Creative biogene Category siRNA Species Reactivities Human

Human PIAS1 siRNA - orb266125 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PIAS1 shRNA Plasmid (Human) - CHH5623 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PIAS1 miRNA 3'UTR clone - MiUTR1H-07881 from Creative biogene Species Reactivities Human

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