PIAS1

Gene Symbol	PIAS1
Entrez Gene	8554
Alt Symbol	DDXBP1, GBP, GU/RH-II, ZMIZ3
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 1
Other Description	AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
Swissprots	Q9UN02 B3KSY9 Q147X4 C5J4B4 B2RB67 O75925 Q99751
Accessions	EAW77804 EAW77805 O75925 AF077951 AAC36702 AF167160 AAD49722 AK094641 BAG52901 AK314515 BAG37114 AY826819 AAX18639 BC053685 BC104646 BC118587 AAI18588 BC121797 AAI21798 EF487997 ABP49565 EF487998 ABP49566 FJ997900 ACR77525 U78524 AAB58488 XM_005254735 XP_005254792 XM_011522126 XP_011520428 XM_011522127 XP_011520429 XM_011522128 XP_011520430 NM_016166 NP_057250
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269|PubMed:1
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Tissue Specificity	Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human PIAS1 ELISA Kit (Cell-Based ELISA) - LS-F2242 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Protein Inhibitor of Activated STAT 1, PIAS1, Human, ELISA Kit - E-EL-H0936 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Inhibitor Of Activated STAT 1, PIAS1, Mouse, ELISA Kit - E-EL-M0969 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Protein Inhibitor Of Activated STAT 1, PIAS1, Rat, ELISA Kit - E-EL-R0804 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor of Activated STAT 1, PIAS1, Rabbit, ELISA Kit - E-EL-RB0929 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor of Activated STAT 1, PIAS1, Chicken, ELISA Kit - E-EL-Ch1369 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Inhibitor of Activated STAT 1, PIAS1, Porcine, ELISA Kit - E-EL-P1967 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor of Activated STAT 1, PIAS1, Guinea Pig, ELISA Kit - E-EL-GP1126 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Inhibitor of Activated STAT 1, PIAS1, Monkey, ELISA Kit - E-EL-MK1989 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human PIAS1 ELISA Kit - HP0101 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PIAS1 ELISA Kit - AP0101 from NeoScientific Category ELISA Kit Prices $380.00, $620.00 Sizes 100 µl, 200 µl

protein inhibitor of activated STAT, 1, ELISA Kit - MBS9332189 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PIAS1 Colorimetric Cell-Based ELISA Kit - CB5554 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human PIAS1(Protein Inhibitor of Activated STAT 1) ELISA Kit - E-EL-H0936 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

PIAS1, ELISA Kit - MBS2514950 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875ng/mL Range 3.125-200ng/mL

PIAS1, ELISA Kit - MBS2510928 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

PIAS1, ELISA Kit - MBS2504024 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875ng/mL Range 3.125-200ng/mL

PIAS1, ELISA Kit - MBS2509448 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

PIAS1, ELISA Kit - MBS2510002 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

PIAS1, ELISA Kit - MBS2507956 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

PIAS1, ELISA Kit - MBS2507452 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

PIAS1, ELISA Kit - MBS2509528 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

Human PIAS1(Protein Inhibitor of Activated STAT 1) ELISA Kit - E-EL-H0936 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 37.5 pg/mLpg/mL Range 62.5~4000 pg/mL

Mouse PIAS1 ELISA Kit (Sandwich ELISA) - LS-F21439 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

PIAS1 (Protein Inhibitor Of Activated STAT 1), CLIA Kit - MBS2531533 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

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