| Gene Symbol |
PIAS1
|
| Entrez Gene |
8554
|
| Alt Symbol |
DDXBP1, GBP, GU/RH-II, ZMIZ3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein inhibitor of activated STAT, 1
|
| Other Description |
AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
|
| Swissprots |
Q9UN02 B3KSY9 Q147X4 C5J4B4 B2RB67 O75925 Q99751
|
| Accessions |
EAW77804 EAW77805 O75925 AF077951 AAC36702 AF167160 AAD49722 AK094641 BAG52901 AK314515 BAG37114 AY826819 AAX18639 BC053685 BC104646 BC118587 AAI18588 BC121797 AAI21798 EF487997 ABP49565 EF487998 ABP49566 FJ997900 ACR77525 U78524 AAB58488 XM_005254735 XP_005254792 XM_011522126 XP_011520428 XM_011522127 XP_011520429 XM_011522128 XP_011520430 NM_016166 NP_057250
|
| Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269|PubMed:1
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
|
| Tissue Specificity |
Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C
|
![Western Blot: PIAS1 Overexpression Lysate (Adult Normal) [NBL1-14384] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PIAS1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8149_PIAS1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14384-img0002.jpg)