PIAS1

Gene Symbol	PIAS1
Entrez Gene	8554
Alt Symbol	DDXBP1, GBP, GU/RH-II, ZMIZ3
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 1
Other Description	AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|DEAD/H box-binding protein 1|E3 SUMO-protein ligase PIAS1|RNA helicase II-binding protein|gu-binding protein|protein inhibitor of activated STAT protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
Swissprots	Q9UN02 B3KSY9 Q147X4 C5J4B4 B2RB67 O75925 Q99751
Accessions	EAW77804 EAW77805 O75925 AF077951 AAC36702 AF167160 AAD49722 AK094641 BAG52901 AK314515 BAG37114 AY826819 AAX18639 BC053685 BC104646 BC118587 AAI18588 BC121797 AAI21798 EF487997 ABP49565 EF487998 ABP49566 FJ997900 ACR77525 U78524 AAB58488 XM_005254735 XP_005254792 XM_011522126 XP_011520428 XM_011522127 XP_011520429 XM_011522128 XP_011520430 NM_016166 NP_057250
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000250, ECO:0000269|PubMed:1
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Tissue Specificity	Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIAS1 full length protein - ab152888 from Abcam Category Protein Source Wheat germ Species Human

Human PIAS1 peptide - ab32218 from Abcam Category Peptide

Human PIAS1 protein fragment - ab152889 from Abcam Category Protein Source Wheat germ Species Human

Human PIAS1 protein fragment - ab152890 from Abcam Category Protein Source Wheat germ Species Human

PIAS1 Antibody Blocking Peptide - LS-E1667 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS1 Antibody Blocking Peptide - LS-E1675 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS1 Antibody Blocking Peptide - LS-E14154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS1 Antibody Blocking Peptide - LS-E14155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS1 Antibody Blocking Peptide - LS-E30921 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PIAS1 Protein - H00008554-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PIAS1 Protein - H00008554-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PIAS1 Protein - H00008554-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIAS1 Blocking Peptide - NBP1-77158PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PIAS1 Peptide - P0308 from Novus Biologicals Category Peptide Species Human

PIAS1 Peptide - P0307 from Novus Biologicals Category Peptide Species Human

PIAS1-Antibody-C-term-Blocking-Peptide - BP1243a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIAS1-Antibody-N-term-Blocking-Peptide - BP1242a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PIAS1 Protein - abx068742 from Abbexa Category Protein Source E.coli Species Human

PIAS1 - H00008554-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PIAS1 - H00008554-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIAS1 - H00008554-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIAS1 - H00008554-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PIAS1 - H00008554-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIAS1 - H00008554-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIAS1 Control Peptide - AP30666CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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