| Gene Symbol |
GPBAR1
|
| Entrez Gene |
151306
|
| Alt Symbol |
BG37, GPCR19, GPR131, M-BAR, TGR5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled bile acid receptor 1
|
| Other Description |
G-protein coupled bile acid receptor 1|G-protein coupled bile acid receptor BG37|G-protein coupled receptor GPCR19|hBG37|hGPCR19|membrane bile acid receptor|membrane-type receptor for bile acids
|
| Swissprots |
B3KV35 Q8TDU6
|
| Accessions |
BAB89314 CAD37291 CAD69712 EAW70598 Q8TDU6 AB086170 BAC65343 AB089307 BAC55235 AK122658 BAG53647 AK122660 BAG53648 BC033625 AAH33625 BI834364 DQ891340 ABM82266 DQ894522 ABM85448 XM_011510743 XP_011509045 XM_011510744 XP_011509046 NM_001077191 NP_001070659 NM_001077194 NP_001070662 NM_170699 NP_733800
|
| Function |
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}.
|
| Tissue Specificity |
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269|PubMed:12044878, ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}.
|