GPBAR1

Gene Symbol GPBAR1
Entrez Gene 151306
Alt Symbol BG37, GPCR19, GPR131, M-BAR, TGR5
Species Human
Gene Type protein-coding
Description G protein-coupled bile acid receptor 1
Other Description G-protein coupled bile acid receptor 1|G-protein coupled bile acid receptor BG37|G-protein coupled receptor GPCR19|hBG37|hGPCR19|membrane bile acid receptor|membrane-type receptor for bile acids
Swissprots B3KV35 Q8TDU6
Accessions BAB89314 CAD37291 CAD69712 EAW70598 Q8TDU6 AB086170 BAC65343 AB089307 BAC55235 AK122658 BAG53647 AK122660 BAG53648 BC033625 AAH33625 BI834364 DQ891340 ABM82266 DQ894522 ABM85448 XM_011510743 XP_011509045 XM_011510744 XP_011509046 NM_001077191 NP_001070659 NM_001077194 NP_001070662 NM_170699 NP_733800
Function Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}.
Tissue Specificity Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269|PubMed:12044878, ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}.

TGR5 (C-16) - sc-48685 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGR5 (K-13) - sc-48687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGR5 (N-15) - sc-48688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGR5 (H-90) - sc-98888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-GPCR TGR5 antibody - ab114081 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab114081 stained HCT116 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab114081, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-GPCR TGR5 antibody - ab117414 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab117414, at 10 ug/ml, staining GPCR TGR5 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistryfollowed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen

Anti-GPCR TGR5 antibody - ab71988 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR TGR5 antibody (ab71988) at 3 µg/mlLane 1 : human kidney lysateLane 2 : human kidney lysate with immunising peptide

Anti-GPCR TGR5 antibody - ab72531 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR TGR5 antibody (ab72531) at 1/5000 dilutionLane 1 : Pre-immune serumLane 2 : mouse spleen lysate.

Anti-GPCR TGR5 antibody - ab72608 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Lane 2 : Anti-GPCR TGR5 antibody (ab72608) at 1/1000 dilutionLanes 3 - 4 : Anti-GPCR TGR5 antibody (ab72608) at 1/5000 dilutionLane 1 : Pre-immune serumLane 2 : Human spleen lysateLane 3 : Mouse spleen lysateLane 4 : Rat spleen lysate

Anti-GPBAR1 / TGR5 Antibody (C-Terminus) IHC-plus™ - LS-A1937 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPBAR1 / TGR5 Antibody (C-Terminus) IHC-plus™ - LS-A1936 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPBAR1 / TGR5 Antibody (aa298-330) - LS-C190868 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPBAR1 / TGR5 Antibody (aa1-50) - LS-C190869 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPBAR1 / TGR5 Antibody (aa11-60) - LS-C120703 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using GPBAR Antibody. The picture on the right is treated with the synthesized peptide.

Anti-GPBAR1 / TGR5 Antibody (C-Terminus) - LS-C151645 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GPBAR1 / TGR5 antibody Western Blot of MCF7.

Anti-GPBAR1 / TGR5 Antibody (aa200-250) - LS-C190870 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPBAR1 / TGR5 Antibody (aa250-300) - LS-C190871 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPBAR1 / TGR5 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1935 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Uterus, Endometrium: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-GPBAR1 / TGR5 Antibody - LS-C47388 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of BG37/TGR5 in spleen lysate. Lane 1 shows pre-immune sera. Lanes 2, 3 and 4 show antibody tested on human (1:1000), mouse (1:5000) and rat (1:5000) spleen lysate, respectively.

Anti-GPBAR1 / TGR5 Antibody - LS-C47389 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of BG37/TGR5 in spleen lysate. Lane1 shows pre-immune sera. Lanes 2, 3 and 4 show antibody tested on human (1:1000), mouse (1:5000) and rat (1:5000) spleen lysate, respectively.

Anti-GPBAR1 / TGR5 Antibody - LS-C47374 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of BG37/TGR5 in spleen lysate. Lane 1 shows pre-immune sera. Lane 2 shows antibody tested at 1:5000 on mouse spleen lysate.

Anti-GPBAR1 / TGR5 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1933 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGR5 antibody LS-A1933 IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPBAR1 / TGR5 Antibody (Internal) IHC-plus™ - LS-B8783 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GPBAR1 / TGR5 antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPBAR1 / TGR5 Antibody (aa302-322) IHC-plus™ - LS-B1798 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGR5 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1798 concentration 10 ug/ml.

Anti-GPBAR1 / TGR5 Antibody (aa298-330) - LS-C190867 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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