| Gene Symbol |
RAB1B
|
| Entrez Gene |
81876
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB1B, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-1B|small GTP-binding protein
|
| Swissprots |
Q9H0U4 A8K7S1
|
| Accessions |
Q9H0U4 AF092437 AAP97212 AJ245875 CAC21570 AK292086 BAF84775 AK315333 BAG37733 AL136635 CAB66570 AM393195 CAL38073 BC028331 BC071169 AAH71169 BG717501 CR533462 CAG38493 U66621 AAC51196 NM_030981 NP_112243
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. {ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:9437002}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}.
|
| Top Pathways |
Legionellosis
|