Gene Symbol | RAB1B |
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Entrez Gene | 81876 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB1B, member RAS oncogene family |
Other Description | ras-related protein Rab-1B|small GTP-binding protein |
Swissprots | Q9H0U4 A8K7S1 |
Accessions | Q9H0U4 AF092437 AAP97212 AJ245875 CAC21570 AK292086 BAF84775 AK315333 BAG37733 AL136635 CAB66570 AM393195 CAL38073 BC028331 BC071169 AAH71169 BG717501 CR533462 CAG38493 U66621 AAC51196 NM_030981 NP_112243 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. {ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:9437002}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}. |
Top Pathways | Legionellosis |
Active rat RAB1B full length protein - ab90789 from Abcam
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RAB1B Antibody Blocking Peptide - LS-E2724 from LifeSpan Bioscience
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RAB1B Antibody Blocking Peptide - LS-E23377 from LifeSpan Bioscience
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RAB1B Recombinant Protein - H00081876-P01 from Novus Biologicals
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RAB1B Partial Recombinant Protein - H00081876-Q01 from Novus Biologicals
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Recombinant Human RAB1B Protein - NBP1-50912 from Novus Biologicals
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RAB1B-Antibody-C-term-Blocking-peptide - BP13810b from Abgent, a WuXi AppTec company
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RAB1B Protein (OPPA02494) - OPPA02494 from Aviva Systems Biology
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Human RAB1B (Fc Tag) protein - orb232373 from Biorbyt
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Human RAB1B protein - orb169135 from Biorbyt
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RAB1B protein (His tag) - 80R-1589 from Fitzgerald
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RAB1B (1-201, His-tag) - AR09768PU-L from Acris Antibodies
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RAB1B (1-201, His-tag) - AR09768PU-N from Acris Antibodies
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RAB1B - H00081876-P01-10 from Acris Antibodies
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RAB1B - H00081876-P01-25 from Acris Antibodies
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RAB1B - H00081876-Q01-10 from Acris Antibodies
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RAB1B - H00081876-Q01-25 from Acris Antibodies
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RAB1B, Member RAS Oncogene Family, Human Recombinant - 228-12766-1 from RayBiotech
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Recombinant Human RAB1B, Member RAS Oncogene Family - 228-12766-2 from RayBiotech
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Recombinant Human RAB1B, Member RAS Oncogene Family - 228-12766-3 from RayBiotech
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RAB1B, 1-201aa, Human, His tag, E.coli - 01-RAB1B from ARP American Research Products
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RAB1B fusion protein - Ag12069 from Proteintech Group
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RAB1B fusion protein - Ag12197 from Proteintech Group
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RAB1B Human - PRPS-052 from NeoScientific
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Recombinant Human RAB1B, Member RAS Oncogene Family Protein - BP002333-PRO-045 from Syd Labs
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