Gene Symbol | RAB1B |
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Entrez Gene | 81876 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB1B, member RAS oncogene family |
Other Description | ras-related protein Rab-1B|small GTP-binding protein |
Swissprots | Q9H0U4 A8K7S1 |
Accessions | Q9H0U4 AF092437 AAP97212 AJ245875 CAC21570 AK292086 BAF84775 AK315333 BAG37733 AL136635 CAB66570 AM393195 CAL38073 BC028331 BC071169 AAH71169 BG717501 CR533462 CAG38493 U66621 AAC51196 NM_030981 NP_112243 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. {ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:9437002}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}. |
Top Pathways | Legionellosis |
Rab 1B (G-20) - sc-599 from Santa Cruz Biotechnology
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Rab 1B (E-12) - sc-26545 from Santa Cruz Biotechnology
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Rab 1B (P-12) - sc-26544 from Santa Cruz Biotechnology
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Rab 1B (LD-S3) - sc-130474 from Santa Cruz Biotechnology
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Anti-RAB1B antibody - ab76721 from Abcam
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Anti-RAB1B antibody - ab116336 from Abcam
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Anti-RAB1B Antibody (C-Terminus) - LS-C151624 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, AP) - LS-C217079 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, Biotin) - LS-C217081 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, FITC) - LS-C217082 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, APC) - LS-C217080 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, Azide-free, HRP) - LS-C217083 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194, PE) - LS-C217084 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa165-194) - LS-C324465 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa91-202, Azide-free) - LS-C328425 from LifeSpan Bioscience
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Anti-RAB1B Antibody (aa166-194) - LS-C162362 from LifeSpan Bioscience
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Anti-RAB1B Antibody (clone 1B2) - LS-C134105 from LifeSpan Bioscience
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RAB1B Antibody - NBP1-98500 from Novus Biologicals
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RAB1B Antibody (1B2) - H00081876-M02 from Novus Biologicals
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RAB1B Antibody - H00081876-A01 from Novus Biologicals
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Monoclonal Anti-RAB1B antibody produced in mouse - SAB1400720 from Sigma-Aldrich
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ANTI-RAB1B (C-TERM) antibody produced in rabbit - SAB1304361 from Sigma-Aldrich
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Anti-RAB1B antibody produced in rabbit - SAB2107828 from Sigma-Aldrich
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RAB1B antibody - C-terminal region (ARP64096_P050) - ARP64096_P050 from Aviva Systems Biology
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RAB1B-Antibody-C-term - AP13810b from Abgent, a WuXi AppTec company
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