| Gene Symbol | CLCN5 |
|---|---|
| Entrez Gene | 1184 |
| Alt Symbol | CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chloride channel, voltage-sensitive 5 |
| Other Description | H(+)/Cl(-) exchange transporter 5|chloride transporter ClC-5|voltage-gated chloride ion channel CLCN5 |
| Swissprots | Q5JQD5 B3KPN6 P51795 A1L475 Q7RTN8 |
| Accessions | EAW89929 P51795 AA743724 AK021494 AK025562 AK056560 BAG51748 AK092049 BAG52474 AK290940 BAF83629 AK308089 BC051691 BC130429 AAI30430 BC130431 AAI30432 BF513571 BK000969 DAA01544 BX950885 DA652242 DA737534 HQ258649 ADR83400 X81836 CAA57430 X91906 CAA63000 XM_011543888 XP_011542190 XM_011543889 XP_011542191 NM_000084 NP_000075 NM_001127898 NP_001121370 NM_001127899 NP_001121371 NM_001272102 NP_001259031 NM_001282163 NP_001269092 |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. |
| Tissue Specificity | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. {ECO:0000269|PubMed:10198195}. |
chloride channel 5, ELISA Kit - MBS9338378 from MyBioSource
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H (+)/Cl (-) exchange transporter 5, ELISA Kit - MBS280411 from MyBioSource
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Human CLCN5 ELISA Kit - E078976 from Biobool
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H (+)/Cl (-) exchange transporter 5, ELISA Kit - MBS285149 from MyBioSource
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H (+)/Cl (-) exchange transporter 5, ELISA Kit - MBS284103 from MyBioSource
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