Gene Symbol | CLCN5 |
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Entrez Gene | 1184 |
Alt Symbol | CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2 |
Species | Human |
Gene Type | protein-coding |
Description | chloride channel, voltage-sensitive 5 |
Other Description | H(+)/Cl(-) exchange transporter 5|chloride transporter ClC-5|voltage-gated chloride ion channel CLCN5 |
Swissprots | Q5JQD5 B3KPN6 P51795 A1L475 Q7RTN8 |
Accessions | EAW89929 P51795 AA743724 AK021494 AK025562 AK056560 BAG51748 AK092049 BAG52474 AK290940 BAF83629 AK308089 BC051691 BC130429 AAI30430 BC130431 AAI30432 BF513571 BK000969 DAA01544 BX950885 DA652242 DA737534 HQ258649 ADR83400 X81836 CAA57430 X91906 CAA63000 XM_011543888 XP_011542190 XM_011543889 XP_011542191 NM_000084 NP_000075 NM_001127898 NP_001121370 NM_001127899 NP_001121371 NM_001272102 NP_001259031 NM_001282163 NP_001269092 |
Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. |
Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. |
Tissue Specificity | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. {ECO:0000269|PubMed:10198195}. |
CLC-5 CRISPR/Cas9 KO Plasmid (h) - sc-404859 from Santa Cruz Biotechnology
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CLC-5 HDR Plasmid (h) - sc-404859-HDR from Santa Cruz Biotechnology
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CLC-5 Double Nickase Plasmid (h) - sc-404859-NIC from Santa Cruz Biotechnology
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CLC-5 Double Nickase Plasmid (h2) - sc-404859-NIC-2 from Santa Cruz Biotechnology
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CLC-5 CRISPR Activation Plasmid (h) - sc-404859-ACT from Santa Cruz Biotechnology
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CLC-5 CRISPR Activation Plasmid (h2) - sc-404859-ACT-2 from Santa Cruz Biotechnology
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CLC-5 Lentiviral Activation Particles (h) - sc-404859-LAC from Santa Cruz Biotechnology
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CLC-5 Lentiviral Activation Particles (h2) - sc-404859-LAC-2 from Santa Cruz Biotechnology
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CLC-5 siRNA (h) - sc-42385 from Santa Cruz Biotechnology
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CLC-5 shRNA Plasmid (h) - sc-42385-SH from Santa Cruz Biotechnology
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CLC-5 shRNA (h) Lentiviral Particles - sc-42385-V from Santa Cruz Biotechnology
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CLC-5 siRNA (chicken) - sc-270042 from Santa Cruz Biotechnology
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CLC-5 shRNA Plasmid (chicken) - sc-270042-SH from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1621 from Sigma-Aldrich
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CLCN5 siRNA (Human) - CRH0846 from Cohesion Biosciences
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CLCN5 RNAi - H00001184-R01 from Novus Biologicals
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CLCN5 - MBS8209491 from MyBioSource
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CLCN5 shRNA Plasmid (Human) - CHH0846 from Cohesion Biosciences
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CLCN5 miRNA 3'UTR clone - MiUTR1H-02186 from Creative biogene
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