| Gene Symbol |
CLCN5
|
| Entrez Gene |
1184
|
| Alt Symbol |
CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel, voltage-sensitive 5
|
| Other Description |
H(+)/Cl(-) exchange transporter 5|chloride transporter ClC-5|voltage-gated chloride ion channel CLCN5
|
| Swissprots |
Q5JQD5 B3KPN6 P51795 A1L475 Q7RTN8
|
| Accessions |
EAW89929 P51795 AA743724 AK021494 AK025562 AK056560 BAG51748 AK092049 BAG52474 AK290940 BAF83629 AK308089 BC051691 BC130429 AAI30430 BC130431 AAI30432 BF513571 BK000969 DAA01544 BX950885 DA652242 DA737534 HQ258649 ADR83400 X81836 CAA57430 X91906 CAA63000 XM_011543888 XP_011542190 XM_011543889 XP_011542191 NM_000084 NP_000075 NM_001127898 NP_001121370 NM_001127899 NP_001121371 NM_001272102 NP_001259031 NM_001282163 NP_001269092
|
| Function |
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}.
|
| Tissue Specificity |
Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. {ECO:0000269|PubMed:10198195}.
|
![Western Blot: CLCN5 Overexpression Lysate (Adult Normal) [NBL1-09234] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLCN5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5605_CLCN5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09234-img0002.jpg)