RNF41
| Gene Symbol | RNF41 |
|---|---|
| Entrez Gene | 10193 |
| Alt Symbol | FLRF, NRDP1, SBBI03 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein 41, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase NRDP1|fetal liver ring finger|neuregulin receptor degradation protein-1 |
| Swissprots | B2RBT8 Q9H4P4 A6NFW0 O75598 |
| Accessions | EAW96909 EAW96910 EAW96911 Q9H4P4 AF077599 AAC27647 AK300752 BAG62420 AK304576 BAG65365 AK314811 BAG37335 AL080105 AY007109 AAG01988 BC011626 BC024284 BC032637 AAH32637 BC036267 BC095418 BI562407 BP201682 BU170070 CB989647 DC316022 EU446758 ABZ92287 XM_005268561 XP_005268618 XM_011537734 XP_011536036 XM_011537735 XP_011536037 XR_944473 NM_001242826 NP_001229755 NM_005785 NP_005776 NM_194358 NP_919339 NM_194359 NP_919340 NR_040053 |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 acti |
| Tissue Specificity | Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}. |
| Top Pathways | Endocytosis |
Nrdp1 (B-8) - sc-374120 from Santa Cruz Biotechnology
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Nrdp1 (A-6) - sc-365622 from Santa Cruz Biotechnology
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Nrdp1 (E-14) - sc-79996 from Santa Cruz Biotechnology
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Nrdp1 (FL-317) - sc-98353 from Santa Cruz Biotechnology
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Nrdp1 (L-15) - sc-79997 from Santa Cruz Biotechnology
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Anti-RNF41 antibody - ab151231 from Abcam
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Anti-RNF41 antibody - ab84409 from Abcam
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Anti-RNF41 antibody - ab103634 from Abcam
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Anti-RNF41 antibody - ab67990 from Abcam
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Anti-RNF41 antibody - C-terminal - ab200460 from Abcam
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Anti-RNF41 antibody - N-terminal - ab200457 from Abcam
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Anti-RNF41 Antibody (aa250-300) - LS-C66193 from LifeSpan Bioscience
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Anti-RNF41 Antibody (C-Terminus) - LS-C66194 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, AP) - LS-C240147 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, APC) - LS-C240148 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, Biotin) - LS-C240149 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, FITC) - LS-C240150 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, Azide-free, HRP) - LS-C248031 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281, PE) - LS-C240151 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa250-300) - LS-C286991 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa254-281) - LS-C324748 from LifeSpan Bioscience
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Anti-RNF41 Antibody (C-Terminus) - LS-C286990 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa74-123) - LS-C80101 from LifeSpan Bioscience
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Anti-RNF41 Antibody (aa255-281) - LS-C158878 from LifeSpan Bioscience
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Anti-RNF41 Antibody (C-Terminus) - LS-C286384 from LifeSpan Bioscience
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