RNF41

Gene Symbol	RNF41
Entrez Gene	10193
Alt Symbol	FLRF, NRDP1, SBBI03
Species	Human
Gene Type	protein-coding
Description	ring finger protein 41, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase NRDP1|fetal liver ring finger|neuregulin receptor degradation protein-1
Swissprots	B2RBT8 Q9H4P4 A6NFW0 O75598
Accessions	EAW96909 EAW96910 EAW96911 Q9H4P4 AF077599 AAC27647 AK300752 BAG62420 AK304576 BAG65365 AK314811 BAG37335 AL080105 AY007109 AAG01988 BC011626 BC024284 BC032637 AAH32637 BC036267 BC095418 BI562407 BP201682 BU170070 CB989647 DC316022 EU446758 ABZ92287 XM_005268561 XP_005268618 XM_011537734 XP_011536036 XM_011537735 XP_011536037 XR_944473 NM_001242826 NP_001229755 NM_005785 NP_005776 NM_194358 NP_919339 NM_194359 NP_919340 NR_040053
Function	Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 acti
Tissue Specificity	Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF41 full length protein - ab160864 from Abcam Category Protein Source Wheat germ Species Human

Human RNF41 protein fragment - ab160865 from Abcam Category Protein Source Wheat germ Species Human

RNF41 Antibody Blocking Peptide - LS-E5984 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF41 Antibody Blocking Peptide - LS-E12336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF41 Protein - H00010193-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF41 Recombinant Protein - H00010193-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RNF41-Antibody-C-term-Blocking-Peptide - BP18548b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF41 - H00010193-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF41 - H00010193-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF41 - H00010193-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF41 - H00010193-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF41 fusion protein - Ag11123 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RNF41 fusion protein - ag11076 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RNF41, His-tagged - RNF41-2346H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase NRDP1(RNF41) - CSB-YP880976HU CSB-EP880976HU CSB-BP880976HU CSB-MP880976HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF41 Protein - abx163490 from Abbexa Category Protein Species Human, Mouse, Rat

RNF41 (transcript variant 2) - TP307568 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RNF41 (full length, N-term HIS tag, transcript variant 3) - TP760790 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

RNF41 Protein - NBP1-87087PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RNF41 Peptide, Human - M34GP13439H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human RNF41 protein - orb54541 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

E3 ubiquitin-protein ligase NRDP1 (RNF41), Recombinant Protein - MBS1409331 from MyBioSource Category Protein Prices $1,075.00, $1,075.00, $1,305.00, $1,305.00, $1,685.00, $1,685.00, $2,150.00, $2,150.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RNF41 Recombinant Protein (Human) (OPCA05028) - OPCA05028 from Aviva Systems Biology Category Protein Species Human

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