RNF41
| Gene Symbol | RNF41 |
|---|---|
| Entrez Gene | 10193 |
| Alt Symbol | FLRF, NRDP1, SBBI03 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein 41, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase NRDP1|fetal liver ring finger|neuregulin receptor degradation protein-1 |
| Swissprots | B2RBT8 Q9H4P4 A6NFW0 O75598 |
| Accessions | EAW96909 EAW96910 EAW96911 Q9H4P4 AF077599 AAC27647 AK300752 BAG62420 AK304576 BAG65365 AK314811 BAG37335 AL080105 AY007109 AAG01988 BC011626 BC024284 BC032637 AAH32637 BC036267 BC095418 BI562407 BP201682 BU170070 CB989647 DC316022 EU446758 ABZ92287 XM_005268561 XP_005268618 XM_011537734 XP_011536036 XM_011537735 XP_011536037 XR_944473 NM_001242826 NP_001229755 NM_005785 NP_005776 NM_194358 NP_919339 NM_194359 NP_919340 NR_040053 |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 acti |
| Tissue Specificity | Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}. |
| Top Pathways | Endocytosis |
Nrdp1 CRISPR/Cas9 KO Plasmid (h) - sc-402973 from Santa Cruz Biotechnology
|
||||||||
Nrdp1 HDR Plasmid (h) - sc-402973-HDR from Santa Cruz Biotechnology
|
||||||||
Nrdp1 Double Nickase Plasmid (h) - sc-402973-NIC from Santa Cruz Biotechnology
|
||||||||
Nrdp1 Double Nickase Plasmid (h2) - sc-402973-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Nrdp1 CRISPR Activation Plasmid (h) - sc-402973-ACT from Santa Cruz Biotechnology
|
||||||||
Nrdp1 CRISPR Activation Plasmid (h2) - sc-402973-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Nrdp1 Lentiviral Activation Particles (h) - sc-402973-LAC from Santa Cruz Biotechnology
|
||||||||
Nrdp1 Lentiviral Activation Particles (h2) - sc-402973-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Nrdp1 siRNA (h) - sc-75956 from Santa Cruz Biotechnology
|
||||||||
Nrdp1 shRNA Plasmid (h) - sc-75956-SH from Santa Cruz Biotechnology
|
||||||||
Nrdp1 shRNA (h) Lentiviral Particles - sc-75956-V from Santa Cruz Biotechnology
|
||||||||
RNF41 RNAi - H00010193-R02 from Novus Biologicals
|
||||||||
RNF41 RNAi - H00010193-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU135161 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18437 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18437 from Sigma-Aldrich
|
||||||||
RNF41 siRNA (Human) - CRH6882 from Cohesion Biosciences
|
||||||||
RNF41 RNAi - H00010193-R03 from Novus Biologicals
|
||||||||
RNF41 - MBS8219337 from MyBioSource
|
||||||||
shRNA set against Human RNF41 (NM_194359.2) - SHH397360 from Creative biogene
|
||||||||
RNF41 shRNA Plasmid (Human) - CHH6882 from Cohesion Biosciences
|
||||||||
RNF41 miRNA 3'UTR clone - MiUTR3H-13471 from Creative biogene
|
||||||||
RNF41 miRNA 3'UTR clone - MiUTR3H-13472 from Creative biogene
|
||||||||
RNF41 miRNA 3'UTR clone - MiUTR3H-13473 from Creative biogene
|