RNF41

Gene Symbol	RNF41
Entrez Gene	10193
Alt Symbol	FLRF, NRDP1, SBBI03
Species	Human
Gene Type	protein-coding
Description	ring finger protein 41, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase NRDP1|fetal liver ring finger|neuregulin receptor degradation protein-1
Swissprots	B2RBT8 Q9H4P4 A6NFW0 O75598
Accessions	EAW96909 EAW96910 EAW96911 Q9H4P4 AF077599 AAC27647 AK300752 BAG62420 AK304576 BAG65365 AK314811 BAG37335 AL080105 AY007109 AAG01988 BC011626 BC024284 BC032637 AAH32637 BC036267 BC095418 BI562407 BP201682 BU170070 CB989647 DC316022 EU446758 ABZ92287 XM_005268561 XP_005268618 XM_011537734 XP_011536036 XM_011537735 XP_011536037 XR_944473 NM_001242826 NP_001229755 NM_005785 NP_005776 NM_194358 NP_919339 NM_194359 NP_919340 NR_040053
Function	Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 acti
Tissue Specificity	Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNF41 293T Cell Transient Overexpression Lysate(Denatured) - H00010193-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RNF41 overexpression lysate - LY405109 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RNF41 293 Cell Lysate - 403531 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RNF41 293 Cell Lysate - 407977 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RNF41 Overexpression Lysate (Native) - NBL1-15456 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RNF41 Overexpression Lysate (Native) - NBP2-07703 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Nrdp1 (h): 293T Lysate - sc-115234 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RNF41 Over-expression Lysate Product - GWB-EC245E from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

RNF41 Over-expression Lysate Product - GWB-9CC89E from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

RNF41 Overexpression Lysate (Native) - NBP2-04751 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RNF41 Overexpression Lysate (Native) - NBP2-09823 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RNF41 Overexpression Lysate (Native) - NBP2-10073 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RNF41 Overexpression Lysate (Denatured) - H00010193-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

RNF41 Overexpression Lysate (Denatured) - H00010193-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human RNF41 Knockdown Stable Cell Line - CSC-DC013439 from Creative biogene Category Cell Line Species Human

RNF41 Knockout Cell Line-HeLa - CSC-RT1994 from Creative biogene Category Cell Line Species Human

RNF41 KO Cell Lysate-HeLa - CLKO-1854 from Creative biogene Category Cell Lysate

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