| Gene Symbol |
RNF41
|
| Entrez Gene |
10193
|
| Alt Symbol |
FLRF, NRDP1, SBBI03
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 41, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase NRDP1|fetal liver ring finger|neuregulin receptor degradation protein-1
|
| Swissprots |
B2RBT8 Q9H4P4 A6NFW0 O75598
|
| Accessions |
EAW96909 EAW96910 EAW96911 Q9H4P4 AF077599 AAC27647 AK300752 BAG62420 AK304576 BAG65365 AK314811 BAG37335 AL080105 AY007109 AAG01988 BC011626 BC024284 BC032637 AAH32637 BC036267 BC095418 BI562407 BP201682 BU170070 CB989647 DC316022 EU446758 ABZ92287 XM_005268561 XP_005268618 XM_011537734 XP_011536036 XM_011537735 XP_011536037 XR_944473 NM_001242826 NP_001229755 NM_005785 NP_005776 NM_194358 NP_919339 NM_194359 NP_919340 NR_040053
|
| Function |
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 acti
|
| Tissue Specificity |
Detected in ovary, testis and prostate. {ECO:0000269|PubMed:12411582}.
|
| Top Pathways |
Endocytosis
|