| Gene Symbol |
SMYD3
|
| Entrez Gene |
64754
|
| Alt Symbol |
KMT3E, ZMYND1, ZNFN3A1, bA74P14.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET and MYND domain containing 3
|
| Other Description |
SET and MYND domain-containing protein 3|bA74P14.1 (novel protein)|histone-lysine N-methyltransferase SMYD3|zinc finger MYND domain-containing protein 1|zinc finger protein, subfamily 3A (MYND domain containing), 1|zinc finger, MYND domain containing 1
|
| Swissprots |
Q96AI5 B1AN38 Q86TL8 Q9H7B4 A8K0P0 Q8N5Z6
|
| Accessions |
CAE91805 CCO13822 EAW77139 EAW77140 EAW77141 EAW77142 EAW77143 EAW77144 Q9H7B4 AB057595 BAB86333 AK023594 BAG51208 AK024733 BAB14981 AK289605 BAF82294 AW173130 AY186742 AAO31695 BC017079 AAH17079 BC031010 AAH31010 BC107725 AAI07726 BI916760 BP231249 DQ581453 DQ892580 ABM83506 DQ895797 ABM86723 XM_011544253 XP_011542555 XM_011544254 XP_011542556 XM_011544255 XP_011542557 XM_011544256 XP_011542558 XM_011544257 XP_011542559 XM_011544258 XP_011542560 XM_011544259 XP_011542561 XM_011544260 XP_011542562 XM_011544261 XP_011542563 XR_949153 NM_001167740 NP_001161212 NM_022743 NP_073580
|
| Function |
Histone methyltransferase. Specifically methylates 'Lys- 4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15235609}. Nucleus {ECO:0000269|PubMed:15235609}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
|
| Tissue Specificity |
Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas. {ECO:0000269|PubMed:15235609}.
|