| Gene Symbol |
GLYAT
|
| Entrez Gene |
10249
|
| Alt Symbol |
ACGNAT, CAT, GAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycine-N-acyltransferase
|
| Other Description |
AAc|HRP-1(CLP)|acyl-CoA:glycine N-acyltransferase|aralkyl acyl-CoA N-acyltransferase|aralkyl acyl-CoA:amino acid N-acyltransferase|aralkyl-CoA N-acyltransferase|benzoyl-coenzyme A:glycine N-acyltransferase|glycine N-acyltransferase|glycine N-benzoyltransferase
|
| Swissprots |
Q96QK7 Q6IB77 O14833
|
| Accessions |
EAW73822 EAW73823 EAW73824 Q6IB77 AB013093 AB665285 BAL43174 AF023466 AAB81453 AI253073 AI793012 AI793201 AW024233 BC009785 AAH09785 BG401676 BG617408 BP277146 CB161978 CR456927 CAG33208 DQ892712 ABM83638 DQ895964 ABM86890 DR004166 NM_005838 NP_005829 NM_201648 NP_964011
|
| Function |
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:22475485}.
|
| Tissue Specificity |
Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}.
|
| Top Pathways |
Phenylalanine metabolism
|
![Western Blot: GLYAT Overexpression Lysate (Adult Normal) [NBL1-11133] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GLYAT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3439_GLYAT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11133-img0002.jpg)