Gene Symbol | GLYAT |
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Entrez Gene | 10249 |
Alt Symbol | ACGNAT, CAT, GAT |
Species | Human |
Gene Type | protein-coding |
Description | glycine-N-acyltransferase |
Other Description | AAc|HRP-1(CLP)|acyl-CoA:glycine N-acyltransferase|aralkyl acyl-CoA N-acyltransferase|aralkyl acyl-CoA:amino acid N-acyltransferase|aralkyl-CoA N-acyltransferase|benzoyl-coenzyme A:glycine N-acyltransferase|glycine N-acyltransferase|glycine N-benzoyltransferase |
Swissprots | Q96QK7 Q6IB77 O14833 |
Accessions | EAW73822 EAW73823 EAW73824 Q6IB77 AB013093 AB665285 BAL43174 AF023466 AAB81453 AI253073 AI793012 AI793201 AW024233 BC009785 AAH09785 BG401676 BG617408 BP277146 CB161978 CR456927 CAG33208 DQ892712 ABM83638 DQ895964 ABM86890 DR004166 NM_005838 NP_005829 NM_201648 NP_964011 |
Function | Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:22475485}. |
Tissue Specificity | Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}. |
Top Pathways | Phenylalanine metabolism |
GLYAT CRISPR/Cas9 KO Plasmid (h) - sc-411444 from Santa Cruz Biotechnology
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GLYAT HDR Plasmid (h) - sc-411444-HDR from Santa Cruz Biotechnology
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GLYAT Double Nickase Plasmid (h) - sc-411444-NIC from Santa Cruz Biotechnology
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GLYAT Double Nickase Plasmid (h2) - sc-411444-NIC-2 from Santa Cruz Biotechnology
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GLYAT CRISPR Activation Plasmid (h) - sc-411444-ACT from Santa Cruz Biotechnology
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GLYAT CRISPR Activation Plasmid (h2) - sc-411444-ACT-2 from Santa Cruz Biotechnology
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GLYAT Lentiviral Activation Particles (h) - sc-411444-LAC from Santa Cruz Biotechnology
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GLYAT Lentiviral Activation Particles (h2) - sc-411444-LAC-2 from Santa Cruz Biotechnology
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GLYAT siRNA (h) - sc-75149 from Santa Cruz Biotechnology
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GLYAT shRNA Plasmid (h) - sc-75149-SH from Santa Cruz Biotechnology
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GLYAT shRNA (h) Lentiviral Particles - sc-75149-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9377 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9377 from Sigma-Aldrich
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GLYAT siRNA (Human) - CRH6936 from Cohesion Biosciences
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GLYAT - MBS8226526 from MyBioSource
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shRNA set against Human GLYAT(NM_201648.2) - SHH088715 from Creative biogene
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shRNA set against Human GLYAT(NM_005838.3) - SHH088733 from Creative biogene
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Human GLYAT siRNA - orb267438 from Biorbyt
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GLYAT shRNA Plasmid (Human) - CHH6936 from Cohesion Biosciences
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GLYAT miRNA 3'UTR clone - MiUTR1H-04086 from Creative biogene
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GLYAT miRNA 3'UTR clone - MiUTR3H-09214 from Creative biogene
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