Gene Symbol | GLYAT |
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Entrez Gene | 10249 |
Alt Symbol | ACGNAT, CAT, GAT |
Species | Human |
Gene Type | protein-coding |
Description | glycine-N-acyltransferase |
Other Description | AAc|HRP-1(CLP)|acyl-CoA:glycine N-acyltransferase|aralkyl acyl-CoA N-acyltransferase|aralkyl acyl-CoA:amino acid N-acyltransferase|aralkyl-CoA N-acyltransferase|benzoyl-coenzyme A:glycine N-acyltransferase|glycine N-acyltransferase|glycine N-benzoyltransferase |
Swissprots | Q96QK7 Q6IB77 O14833 |
Accessions | EAW73822 EAW73823 EAW73824 Q6IB77 AB013093 AB665285 BAL43174 AF023466 AAB81453 AI253073 AI793012 AI793201 AW024233 BC009785 AAH09785 BG401676 BG617408 BP277146 CB161978 CR456927 CAG33208 DQ892712 ABM83638 DQ895964 ABM86890 DR004166 NM_005838 NP_005829 NM_201648 NP_964011 |
Function | Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. {ECO:0000269|PubMed:22475485, ECO:0000269|PubMed:7802672}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:22475485}. |
Tissue Specificity | Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. {ECO:0000269|PubMed:22475485}. |
Top Pathways | Phenylalanine metabolism |
Human GLYAT full length protein - ab109928 from Abcam
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GLYAT Antibody Blocking Peptide - LS-E2156 from LifeSpan Bioscience
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GLYAT Antibody Blocking Peptide - LS-E17598 from LifeSpan Bioscience
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GLYAT Partial Recombinant Protein - H00010249-Q01 from Novus Biologicals
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GLYAT Recombinant Protein - H00010249-P01 from Novus Biologicals
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Recombinant Human GLYAT Protein - NBP1-72365 from Novus Biologicals
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GLYAT-Antibody-Center-Blocking-peptide - BP13064c from Abgent, a WuXi AppTec company
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Human GLYAT protein - orb168401 from Biorbyt
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GLYAT Blocking Peptide - 33R-3880 from Fitzgerald
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GLYAT / ACGNAT (1-296, His-tag) - AR39059PU-L from Acris Antibodies
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GLYAT / ACGNAT (1-296, His-tag) - AR39059PU-N from Acris Antibodies
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GLYAT / ACGNAT - H00010249-P01-10 from Acris Antibodies
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GLYAT / ACGNAT - H00010249-P01-25 from Acris Antibodies
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GLYAT / ACGNAT - H00010249-Q01-10 from Acris Antibodies
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GLYAT / ACGNAT - H00010249-Q01-25 from Acris Antibodies
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Glycine-N-Acyltransferase, Human Recombinant - 228-12299-1 from RayBiotech
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Recombinant Human Glycine-N-Acyltransferase - 228-12299-2 from RayBiotech
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Recombinant Human Glycine-N-Acyltransferase - 228-12299-3 from RayBiotech
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GLYAT, 1-296aa, Human, His tag, E.coli - 01-P1119 from ARP American Research Products
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GLYAT fusion protein - ag1351 from Proteintech Group
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GLYAT Human - ENPS-155 from NeoScientific
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Recombinant Human Glycine-N-Acyltransferase Enzyme - BP002795-ENZ-148 from Syd Labs
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GLYAT, 1-296aa, Recombinant Protein - GWB-P0919I from Genway Biotech
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Recombinant Human GLYAT, His-tagged - GLYAT-3574H from Creative Biomart
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Recombinant Human GLYAT, His-tagged - GLYAT-27658TH from Creative Biomart
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