NCKIPSD

Gene Symbol	NCKIPSD
Entrez Gene	51517
Alt Symbol	AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH
Species	Human
Gene Type	protein-coding
Description	NCK interacting protein with SH3 domain
Other Description	54 kDa VacA-interacting protein|54 kDa vimentin-interacting protein|90 kDa SH3 protein interacting with Nck|NCK-interacting protein with SH3 domain|SH3 adapter protein SPIN90|SH3 protein interacting with Nck, 90 kDa|WASP-interacting SH3-domain protein|dia interacting protein|dia-interacting protein 1|diaphanous protein interacting protein|wiskott-Aldrich syndrome protein-interacting protein
Swissprots	Q8TC10 Q9NZQ3 Q6SPF3 Q9UGM8 Q6GU34 B4DFL5
Accessions	BAB63204 BAB63205 EAW64915 EAW64916 EAW64917 EAW64918 Q9NZQ3 AF178432 AAF35985 AF303581 AAK09094 AI863106 AJ242655 CAB65089 AK294151 BAG57476 AY453794 AAR83735 BC006255 BC016052 AAH16052 BC026280 AAH26280 HY010884 HY050918 JF432321 ADZ15538 NM_016453 NP_057537 NM_184231 NP_909119
Function	Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
Subcellular Location	Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Tissue Specificity	Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269|PubMed:10619843}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NCKIPSD 293T Cell Transient Overexpression Lysate(Denatured) - H00051517-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NCKIPSD overexpression lysate - LY405211 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NCKIPSD Overexpression Lysate (Denatured) - H00051517-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

NCKIPSD Overexpression Lysate (Native) - NBP2-04774 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human NCKIPSD Knockdown Stable Cell Line - CSC-DC010190 from Creative biogene Category Cell Line Species Human

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