NCKIPSD

Gene Symbol NCKIPSD
Entrez Gene 51517
Alt Symbol AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH
Species Human
Gene Type protein-coding
Description NCK interacting protein with SH3 domain
Other Description 54 kDa VacA-interacting protein|54 kDa vimentin-interacting protein|90 kDa SH3 protein interacting with Nck|NCK-interacting protein with SH3 domain|SH3 adapter protein SPIN90|SH3 protein interacting with Nck, 90 kDa|WASP-interacting SH3-domain protein|dia interacting protein|dia-interacting protein 1|diaphanous protein interacting protein|wiskott-Aldrich syndrome protein-interacting protein
Swissprots Q8TC10 Q9NZQ3 Q6SPF3 Q9UGM8 Q6GU34 B4DFL5
Accessions BAB63204 BAB63205 EAW64915 EAW64916 EAW64917 EAW64918 Q9NZQ3 AF178432 AAF35985 AF303581 AAK09094 AI863106 AJ242655 CAB65089 AK294151 BAG57476 AY453794 AAR83735 BC006255 BC016052 AAH16052 BC026280 AAH26280 HY010884 HY050918 JF432321 ADZ15538 NM_016453 NP_057537 NM_184231 NP_909119
Function Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
Subcellular Location Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
Tissue Specificity Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269|PubMed:10619843}.

SPIN90 (H-300) - sc-98362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPIN90 (H-300): sc-98362. Western blot analysis of SPIN90 expression in non-transfected: sc-117752 (A) and mouse SPIN90 transfected: sc-123746 (B) 293T whole cell lysates.

SPIN90 (B-3) - sc-377405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPIN90 (B-3): sc-377405. Western blot analysis of SPIN90 expression in Jurkat nuclear extract.

SPIN90 (B-6) - sc-514232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPIN90 (B-6): sc-514232. Western blot analysis of SPIN90 expression in JAR (A), HeLa (B) and HCT-116 (C) whole cell lysates.

SPIN90 (G-19) - sc-79100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPIN90 (N-17) - sc-79102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPIN90 (N-17): sc-79102. Western blot analysis of SPIN90 expression in Jurkat nuclear extract.

SPIN90 (S-17) - sc-79103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPIN90 (5) - sc-293054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPIN90 (5): sc-293054. Western blot analysis of SPIN90 expression in JAR whole cell lysate.

SPIN90 (2614C1a) - sc-81383 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SPIN90 (2614C1a): sc-81383. Western blot analysis of SPIN90 expression in non-transfected: sc-117752 (A) and mouse SPIN90 transfected: sc-123746 (B) 293T whole cell lysates.

Anti-NCKIPSD antibody - ab88467 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-NCKIPSD antibody (ab88467) at 1 µg/ml + rat brain tissue lysate at 50 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-NCKIPSD antibody - ab75353 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NCKIPSD antibody - ab128154 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab128154, at 1/250, staining NCKIPSD in formalin fixed, paraffin embedded Human testicular seminoma tissue by Immunohistochemistry. Detected using DAB staining.

Anti-NCKIPSD antibody [2614C1a] - ab58676 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2614C1a
Anti-NCKIPSD antibody [2614C1a] (ab58676)

Anti-NCKIPSD / AF3P21 Antibody (SH3 Domain) - LS-C73188 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NCKIPSD / AF3P21 Antibody (C-Terminus) - LS-C144919 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NCKIPSD / AF3P21 Antibody (clone 2614C1a) - LS-C184577 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2614C1a

Anti-NCKIPSD / AF3P21 Antibody (aa672-722) - LS-C289370 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NCKIPSD / AF3P21 Antibody (aa471-520) - LS-C135538 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NCKIPSD / AF3P21 antibody Western Blot of Fetal Liver.

Anti-NCKIPSD / AF3P21 Antibody (aa600-650) - LS-C289368 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SPIN90 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-SPIN90 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-NCKIPSD / AF3P21 Antibody (clone 2614C1a) - LS-C342855 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2614C1a
Western blot analysis of immunized recombinant protein, using anti-NCKIPSD monoclonal antibody.

Anti-NCKIPSD / AF3P21 Antibody (aa362-411) - LS-C170313 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NCKIPSD / AF3P21 Antibody (aa600-650) - LS-C286935 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SPIN90 by Immunohistochemistry. Sample: FFPE section of human seminoma. Antibody: Affinity purified rabbit anti-SPIN90 used at a dilution of 1:250.

NCKIPSD Antibody - H00051517-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: NCKIPSD Antibody [H00051517-B01] - NCKIPSD MaxPab polyclonal antibody. Western Blot analysis of NCKIPSD expression in rat brain.

NCKIPSD Antibody - 27110002 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

NCKIPSD Antibody - NBP1-42664 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: NCKIPSD Antibody [NBP1-42664] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- SPIN90 used at a dilution of 1:500 (0.4ug/ml). Detection: DAB. Counterstain: IHC Hematoxylin (blue).

NCKIPSD Antibody - NBP1-42663 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: NCKIPSD Antibody [NBP1-42663] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- SPIN90 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
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