| Gene Symbol | NCKIPSD |
|---|---|
| Entrez Gene | 51517 |
| Alt Symbol | AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH |
| Species | Human |
| Gene Type | protein-coding |
| Description | NCK interacting protein with SH3 domain |
| Other Description | 54 kDa VacA-interacting protein|54 kDa vimentin-interacting protein|90 kDa SH3 protein interacting with Nck|NCK-interacting protein with SH3 domain|SH3 adapter protein SPIN90|SH3 protein interacting with Nck, 90 kDa|WASP-interacting SH3-domain protein|dia interacting protein|dia-interacting protein 1|diaphanous protein interacting protein|wiskott-Aldrich syndrome protein-interacting protein |
| Swissprots | Q8TC10 Q9NZQ3 Q6SPF3 Q9UGM8 Q6GU34 B4DFL5 |
| Accessions | BAB63204 BAB63205 EAW64915 EAW64916 EAW64917 EAW64918 Q9NZQ3 AF178432 AAF35985 AF303581 AAK09094 AI863106 AJ242655 CAB65089 AK294151 BAG57476 AY453794 AAR83735 BC006255 BC016052 AAH16052 BC026280 AAH26280 HY010884 HY050918 JF432321 ADZ15538 NM_016453 NP_057537 NM_184231 NP_909119 |
| Function | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| Subcellular Location | Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes. |
| Tissue Specificity | Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269|PubMed:10619843}. |