| Gene Symbol |
MCM3
|
| Entrez Gene |
4172
|
| Alt Symbol |
HCC5, P1-MCM3, P1.h, RLFB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 3
|
| Other Description |
DNA polymerase alpha holoenzyme-associated protein P1|DNA replication factor MCM3|DNA replication licensing factor MCM3|MCM3 minichromosome maintenance deficient 3|RLF subunit beta|cervical cancer proto-oncogene 5|hRlf beta subunit|minichromosome maintenance deficient 3|p102|replication licensing factor, beta subunit
|
| Swissprots |
B4DWW4 Q9BTR3 P25205 Q9NUE7 Q92660
|
| Accessions |
AAT27321 CBX85467 EAX04366 EAX04367 P25205 AI683709 AK222586 BAD96306 AK299566 BAG61508 AK300754 BAG62421 AK301704 BAG63176 AK312928 BAG35772 AY032603 AAK56392 BC001626 AAH01626 BC003509 AAH03509 BI463632 D38073 BAA07267 DC404097 DQ893654 ABM84580 DQ895840 ABM86766 X62153 CAA44078 NM_001270472 NP_001257401 NM_002388 NP_002379
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
DNA replication, Cell cycle
|
![Western Blot: MCM3 Overexpression Lysate (Adult Normal) [NBL1-12951] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCM3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5625_MCM3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12951-img0002.jpg)