MCM3

Gene Symbol MCM3
Entrez Gene 4172
Alt Symbol HCC5, P1-MCM3, P1.h, RLFB
Species Human
Gene Type protein-coding
Description minichromosome maintenance complex component 3
Other Description DNA polymerase alpha holoenzyme-associated protein P1|DNA replication factor MCM3|DNA replication licensing factor MCM3|MCM3 minichromosome maintenance deficient 3|RLF subunit beta|cervical cancer proto-oncogene 5|hRlf beta subunit|minichromosome maintenance deficient 3|p102|replication licensing factor, beta subunit
Swissprots B4DWW4 Q9BTR3 P25205 Q9NUE7 Q92660
Accessions AAT27321 CBX85467 EAX04366 EAX04367 P25205 AI683709 AK222586 BAD96306 AK299566 BAG61508 AK300754 BAG62421 AK301704 BAG63176 AK312928 BAG35772 AY032603 AAK56392 BC001626 AAH01626 BC003509 AAH03509 BI463632 D38073 BAA07267 DC404097 DQ893654 ABM84580 DQ895840 ABM86766 X62153 CAA44078 NM_001270472 NP_001257401 NM_002388 NP_002379
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Subcellular Location Nucleus.
Top Pathways DNA replication, Cell cycle

Phospho-MCM3 (Ser112) (D3S4M) Rabbit mAb - 12686 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3S4M
Western blot analysis of HeLa cell extracts, untreated (-) or treated with Nocodazole #2190 (100 ng/ml, 24 hr; +), using Phospho-MCM3 (Ser112) (D3S4M) Rabbit mAb (upper), MCM3 (D47B6) Rabbit mAb #4003 (middle) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

MCM3 (D47B6) Rabbit mAb - 4003 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D47B6
Western blot analysis of extracts from various cell types using MCM3 (D47B6) Rabbit mAb.

MCM3 Antibody - 4012 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using MCM3 Antibody.

MCM3 (E-7) - sc-365616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM3 (E-7): sc-365616. Western blot analysis of MCM3 expression in K-562 whole cell lysate.

MCM3 (E-8) - sc-390480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MCM3 (E-8): sc-390480. Western blot analysis of MCM3 expression in K-562 (A) and NIH/3T3 (B) whole cell lysates.

MCM3 (G-19) - sc-9849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MCM3 (G-19): sc-9849. Western blot analysis of MCM3 expression in NIH/3T3 nuclear extract.

MCM3 (H-215) - sc-292857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MCM3 (H-215): sc-292857. Western blot analysis of MCM3 expression in K-562 (A), KNRK (B), NIH/3T3 (C), HeLa (D), COLO 320DM (E) and Jurkat (F) whole cell lysates.

MCM3 (N-19) - sc-9850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MCM3 siRNA (h): sc-35881. Western blot analysis of MCM3 expression in non-transfected control (A) and MCM3 siRNA transfected (B) HeLa cells. Blot probed with MCM3 (N-19): sc-9850. α-actinin (H-2): sc-17829 used as specificity and loading control.

Anti-MCM3 antibody - ab131036 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCM3 antibody (ab131036) at 0.5 µg/mlLane 1 : Hela cell Lysate Lane 2 : Jurkat cell Lysate

Anti-MCM3 antibody - ab3725 from Abcam

Prices $376.00
Sizes 50 µl
Host Goat
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling MCM3 with ab3725 at 1/1000 (1µg/ml). Detection: DAB.

Anti-MCM3 antibody - ab84491 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC analysis of FFPE section of human colon adenocarcinoma using ab84491 at a dilution of 1/250.

Anti-MCM3 antibody - ab84151 from Abcam

Prices $376.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
ab84151, at 1/250 dilution, staining MCM3 in formalin-fixed, paraffin-embedded human ovarian tumor by Immunohistochemistry using DAB detection.

Anti-MCM3 antibody [EPR7080] - ab128923 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7080
All lanes : Anti-MCM3 antibody [EPR7080] (ab128923) at 1/1000 dilutionLane 1 : L6 cell lysateLane 2 : C6 cell lysateLane 3 : RAW 264.7 cell lysateLane 4 : PC-12 cell lysateLane 5 : NIH/3T3 cell lysateLane 6 : HeLa cell lysateLane 7 : K562 cell lysateLane 8 : HepG2 cell lysateLane 9 : U937 cell lysateLane 10 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MCM3 antibody [EPR7081] - ab126723 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7081
All lanes : Anti-MCM3 antibody [EPR7081] (ab126723) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MCM3 antibody - ChIP Grade - ab4460 from Abcam

Prices $403.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling MCM3 with ab4460 at 1/1000 (1µg/ml). Detection: DAB.

Anti-MCM3 Antibody (aa696-745) IHC-plus™ - LS-B6800 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MCM3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6800 concentration 5 ug/ml.

Anti-MCM3 Antibody - LS-C331230 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat brain using MCM3 antibody at dilution of 1:200 (400x lens).

Anti-MCM3 Antibody (aa13-27) - LS-C312806 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MCM3 antibody. IHC(P): Rat Intestine Tissue.

Anti-MCM3 Antibody - LS-C72286 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MCM3 Antibody - LS-C72287 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MCM3 Antibody - LS-C72288 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MCM3 Antibody (aa692-708) - LS-C125923 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MCM3 Antibody - LS-C40924 from LifeSpan Bioscience

Prices $205.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Hela cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-MCM3 antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.

Anti-MCM3 Antibody (aa699-809, clone 10B2435, Azide-free) - LS-C183707 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2435

Anti-MCM3 Antibody (clone 3E11) - LS-C139330 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E11
MCM3 monoclonal antibody (M06), clone 3E11. Western blot of MCM3 expression in human spleen.
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