MCM3

Gene Symbol MCM3
Entrez Gene 4172
Alt Symbol HCC5, P1-MCM3, P1.h, RLFB
Species Human
Gene Type protein-coding
Description minichromosome maintenance complex component 3
Other Description DNA polymerase alpha holoenzyme-associated protein P1|DNA replication factor MCM3|DNA replication licensing factor MCM3|MCM3 minichromosome maintenance deficient 3|RLF subunit beta|cervical cancer proto-oncogene 5|hRlf beta subunit|minichromosome maintenance deficient 3|p102|replication licensing factor, beta subunit
Swissprots B4DWW4 Q9BTR3 P25205 Q9NUE7 Q92660
Accessions AAT27321 CBX85467 EAX04366 EAX04367 P25205 AI683709 AK222586 BAD96306 AK299566 BAG61508 AK300754 BAG62421 AK301704 BAG63176 AK312928 BAG35772 AY032603 AAK56392 BC001626 AAH01626 BC003509 AAH03509 BI463632 D38073 BAA07267 DC404097 DQ893654 ABM84580 DQ895840 ABM86766 X62153 CAA44078 NM_001270472 NP_001257401 NM_002388 NP_002379
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Subcellular Location Nucleus.
Top Pathways DNA replication, Cell cycle

MCM3 CRISPR/Cas9 KO Plasmid (h) - sc-402076 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 HDR Plasmid (h) - sc-402076-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 Double Nickase Plasmid (h) - sc-402076-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 Double Nickase Plasmid (h2) - sc-402076-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 CRISPR Activation Plasmid (h) - sc-402076-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 CRISPR Activation Plasmid (h2) - sc-402076-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 Lentiviral Activation Particles (h) - sc-402076-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 Lentiviral Activation Particles (h2) - sc-402076-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCM3 siRNA (h) - sc-35881 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCM3 shRNA Plasmid (h) - sc-35881-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCM3 shRNA (h) Lentiviral Particles - sc-35881-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU079151 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13118 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13118 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05046 from Sigma-Aldrich

Category miRNA

MCM3 siRNA (Human) - CRH2840 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MCM3 RNAi - H00004172-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MCM3 (NM_002388.4) - SHH339287 from Creative biogene

Category siRNA
Species Reactivities Human

MCM3 shRNA Plasmid (Human) - CHH2840 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MCM3 miRNA 3'UTR clone - MiUTR3H-05233 from Creative biogene

Species Reactivities Human
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