| Gene Symbol |
RNF135
|
| Entrez Gene |
84282
|
| Alt Symbol |
L13, MMFD, REUL, Riplet
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 135
|
| Other Description |
E3 ubiquitin-protein ligase RNF135|RIG-I E3 ubiquitin ligase
|
| Swissprots |
F5GX60 A0AVM5 B2R7G9 B6ZLM5 Q9BSE9 Q8IUD6
|
| Accessions |
EAW80286 Q8IUD6 AB470605 BAG84604 AI634044 AJ496729 CAD43140 AK122646 BAG53638 AK122709 BAG53681 AK226030 AK312979 BAG35816 AY598332 AAT06743 BC005084 AAH05084 BC082262 BC126420 AAI26421 BC126422 AAI26423 BC144143 DA878616 XM_005258043 XP_005258100 XM_006722138 XP_006722201 NM_001184992 NP_001171921 NM_032322 NP_115698 NM_197939 NP_922921
|
| Function |
Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19484123}.
|
| Tissue Specificity |
Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. {ECO:0000269|PubMed:19017631}.
|
![Western Blot: RNF135 Overexpression Lysate (Adult Normal) [NBP2-06044] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF135.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2004_RNF135%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06044-img0001.jpg)
![Western Blot: RNF135 Overexpression Lysate (Adult Normal) [NBP2-10246] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF135.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10027_RNF135%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10246-img0001.jpg)