RNF135

Gene Symbol RNF135
Entrez Gene 84282
Alt Symbol L13, MMFD, REUL, Riplet
Species Human
Gene Type protein-coding
Description ring finger protein 135
Other Description E3 ubiquitin-protein ligase RNF135|RIG-I E3 ubiquitin ligase
Swissprots F5GX60 A0AVM5 B2R7G9 B6ZLM5 Q9BSE9 Q8IUD6
Accessions EAW80286 Q8IUD6 AB470605 BAG84604 AI634044 AJ496729 CAD43140 AK122646 BAG53638 AK122709 BAG53681 AK226030 AK312979 BAG35816 AY598332 AAT06743 BC005084 AAH05084 BC082262 BC126420 AAI26421 BC126422 AAI26423 BC144143 DA878616 XM_005258043 XP_005258100 XM_006722138 XP_006722201 NM_001184992 NP_001171921 NM_032322 NP_115698 NM_197939 NP_922921
Function Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19484123}.
Tissue Specificity Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. {ECO:0000269|PubMed:19017631}.

RNF135 - MBS1270325 from MyBioSource

Species Human
Accession BC126420

human RNF135 ORF clone (NM_032322.3) - CDCH074334 from Creative biogene

Species Human

human RNF135 ORF clone (NM_001184992.1) - CDCH074336 from Creative biogene

Species Human

human RNF135 ORF clone (NM_197939.1) - CDCH074338 from Creative biogene

Species Human

Human RNF135 ORF Clone (BC126420) - CDCS409158 from Creative biogene

Species Human
Accession Q8IUD6

Human RNF135 cDNA Clone(NM_032322.3) - CDFG005957 from Creative biogene

Species Human

Human RNF135 cDNA Clone(NM_197939.1) - CDFG012344 from Creative biogene

Species Human

Human RNF135 cDNA Clone(NM_001184992.1) - CDFH016404 from Creative biogene

Species Human
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