Gene Symbol | RNF135 |
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Entrez Gene | 84282 |
Alt Symbol | L13, MMFD, REUL, Riplet |
Species | Human |
Gene Type | protein-coding |
Description | ring finger protein 135 |
Other Description | E3 ubiquitin-protein ligase RNF135|RIG-I E3 ubiquitin ligase |
Swissprots | F5GX60 A0AVM5 B2R7G9 B6ZLM5 Q9BSE9 Q8IUD6 |
Accessions | EAW80286 Q8IUD6 AB470605 BAG84604 AI634044 AJ496729 CAD43140 AK122646 BAG53638 AK122709 BAG53681 AK226030 AK312979 BAG35816 AY598332 AAT06743 BC005084 AAH05084 BC082262 BC126420 AAI26421 BC126422 AAI26423 BC144143 DA878616 XM_005258043 XP_005258100 XM_006722138 XP_006722201 NM_001184992 NP_001171921 NM_032322 NP_115698 NM_197939 NP_922921 |
Function | Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19484123}. |
Tissue Specificity | Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. {ECO:0000269|PubMed:19017631}. |
Human RNF135 full length protein - ab164552 from Abcam
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RNF135 Antibody Blocking Peptide - LS-E12312 from LifeSpan Bioscience
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RNF135 Antibody Blocking Peptide - LS-E6594 from LifeSpan Bioscience
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RNF135 Antibody Blocking Peptide - LS-E12429 from LifeSpan Bioscience
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RNF135 Antibody Blocking Peptide - LS-E12430 from LifeSpan Bioscience
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Recombinant Human RNF135 Protein - H00084282-P01 from Novus Biologicals
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RNF135-AntibodyC-term-Blocking-peptide - BP19376b from Abgent, a WuXi AppTec company
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MRPL13 protein (His tag) - 80R-2722 from Fitzgerald
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RNF135 - H00084282-P01-10 from Acris Antibodies
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RNF135 - H00084282-P01-25 from Acris Antibodies
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RNF135 fusion protein - ag18816 from Proteintech Group
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RNF135 fusion protein - Ag18821 from Proteintech Group
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Recombinant Human E3 ubiquitin-protein ligase RNF135(RNF135) - CSB-YP811599HU CSB-EP811599HU CSB-BP811599HU CSB-MP811599HU from Cusabio
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RNF135 (transcript variant 1) - TP319438 from Acris Antibodies
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RNF135 (transcript variant 3) - TP329833 from Acris Antibodies
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RNF135 Recombinant Protein Antigen - NBP1-81212PEP from Novus Biologicals
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RNF135 Peptide, Human - M34GP13383H from Creative Peptides
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RNF135 Recombinant Protein Antigen - NBP2-56223PEP from Novus Biologicals
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E3 ubiquitin-protein ligase RNF135 (RNF135), Recombinant Protein - MBS1411302 from MyBioSource
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