| Gene Symbol |
HTR1D
|
| Entrez Gene |
3352
|
| Alt Symbol |
5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
|
| Other Description |
5-HT-1D|5-HT-1D-alpha|5-hydroxytryptamine receptor 1D|serotonin 1D alpha receptor|serotonin receptor 1D
|
| Swissprots |
P28221
|
| Accessions |
AAA35491 EAW95037 P28221 AF498979 AAM21126 BC007720 AAH07720 BT007027 AAP35673 DQ893875 ABM84801 EU176172 ABW03623 M81589 AAA60315 NM_000864 NP_000855
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}; Multi- pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.
|
| Tissue Specificity |
Detected in brain neocortex and caudate nucleus (at protein level). {ECO:0000269|PubMed:1828434}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|