PLN

Gene Symbol	PLN
Entrez Gene	5350
Alt Symbol	CMD1P, CMH18, PLB
Species	Human
Gene Type	protein-coding
Description	phospholamban
Other Description	cardiac phospholamban
Swissprots	P26678
Accessions	AAD55950 EAW48198 P26678 AK311799 BAG34742 BC005269 AAH05269 BP259965 DQ893034 ABM83960 DQ896146 ABM87145 M60411 AAA60109 M63603 AAA60083 NM_002667 NP_002658
Function	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}.
Subcellular Location	Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity	Heart muscle (at protein level). {ECO:0000269|PubMed:17241641}.
Top Pathways	Calcium signaling pathway, Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PLN / Phospholamban ELISA Kit (Sandwich ELISA) - LS-F6888 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human PLN / Phospholamban ELISA Kit (Competitive EIA) - LS-F12384 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.1 ng/ml Range 0.156-10 ng/ml

Human Phospholamban ELISA Kit - abx052130 from Abbexa Category ELISA Kit

Cardiac phospholamban (PLN), Human, ELISA Kit - E01C2393 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cardiac phospholamban, PLN, Human, ELISA Kit - E1884h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Phospholamban, Human, ELISA Kit - E01P0128 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

Phospholipase B (PLB), Human, ELISA Kit - SEC048Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.113ng/mL Range 0.312-20ng/mL

Phospholipase B1, membrane-associated (PLB1), Human, ELISA Kit - CSB-EL018123HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Phospholamban, PLN, Human, ELISA Kit - E-EL-H1947 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Phospholamban, PLN, Rabbit, ELISA Kit - E-EL-RB0796 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Phospholamban, PLN, Chicken, ELISA Kit - E-EL-Ch1346 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Phospholamban, PLN, Porcine, ELISA Kit - E-EL-P0173 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Phospholamban, PLN, Guinea Pig, ELISA Kit - E-EL-GP0113 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Phospholamban, PLN, Monkey, ELISA Kit - E-EL-MK1676 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human PLN ELISA Kit - HP0693 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human PLN ELISA Kit - HP0135 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PLN ELISA Kit - AP0135 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Anserine PLN ELISA Kit - AP0693 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Phospholamban, ELISA Kit - MBS742168 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Phospholamban, ELISA Kit - MBS738087 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholamban, ELISA Kit - MBS022578 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholamban, ELISA Kit - MBS738871 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Phospholamban, ELISA Kit - MBS039735 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholamban, ELISA Kit - MBS733496 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholamban, ELISA Kit - MBS020033 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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