PLN

Gene Symbol	PLN
Entrez Gene	5350
Alt Symbol	CMD1P, CMH18, PLB
Species	Human
Gene Type	protein-coding
Description	phospholamban
Other Description	cardiac phospholamban
Swissprots	P26678
Accessions	AAD55950 EAW48198 P26678 AK311799 BAG34742 BC005269 AAH05269 BP259965 DQ893034 ABM83960 DQ896146 ABM87145 M60411 AAA60109 M63603 AAA60083 NM_002667 NP_002658
Function	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}.
Subcellular Location	Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity	Heart muscle (at protein level). {ECO:0000269|PubMed:17241641}.
Top Pathways	Calcium signaling pathway, Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospholamban protein fragment - ab114227 from Abcam Category Protein Source Wheat germ Species Human

PLN / Phospholamban Antibody Blocking Peptide - LS-E27433 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLN / Phospholamban Antibody Blocking Peptide - LS-E7461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLN / Phospholamban Antibody Blocking Peptide - LS-E10371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Phospholamban Protein - H00005350-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Phospho-PLBT17-Antibody-Blocking-peptide - BP3694a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

PLB-T17-Antibody-Blocking-Peptide - BP9884a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospholamban blocking peptide - GTX88052-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Pig, Rat, Bovine

Human P26678 protein - orb246771 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Phospholamban Peptide - AC21-2257-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Phospholamban - H00005350-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Phospholamban - H00005350-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLN Peptide - 42-818P from ProSci Category Peptide Species Human, Rat

PLN fusion protein - Ag8632 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PLN fusion protein - ag8563 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human PLN - PLN-30732TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PLN, GST-tagged - PLN-1791H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Phospholamban (PLN) - RPB884Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Phospholamban (PLN) - RPB884Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Phospholamban (PLN) - RPB884Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Phospholamban (pS16/T17) Blocking Peptide - CBP4158 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit

Recombinant Phospholipase B (PLB) - RPC048Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Phospholamban (PLN) - RPB884Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cardiac phospholamban(PLN) - CSB-EP018198HU CSB-BP018198HU CSB-MP018198HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Cardiac phospholamban(PLN) - CSB-YP018198HU from Cusabio Category Protein Source Yeast Species Human

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