PLN

Gene Symbol	PLN
Entrez Gene	5350
Alt Symbol	CMD1P, CMH18, PLB
Species	Human
Gene Type	protein-coding
Description	phospholamban
Other Description	cardiac phospholamban
Swissprots	P26678
Accessions	AAD55950 EAW48198 P26678 AK311799 BAG34742 BC005269 AAH05269 BP259965 DQ893034 ABM83960 DQ896146 ABM87145 M60411 AAA60109 M63603 AAA60083 NM_002667 NP_002658
Function	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}.
Subcellular Location	Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity	Heart muscle (at protein level). {ECO:0000269|PubMed:17241641}.
Top Pathways	Calcium signaling pathway, Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

phospholamban siRNA (h) - sc-39143 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

phospholamban shRNA Plasmid (h) - sc-39143-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

phospholamban shRNA (h) Lentiviral Particles - sc-39143-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Phospholamban RNAi - H00005350-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU126511 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16992 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16992 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PLN siRNA (Human) - CRH3589 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PLN (NM_002667.3) - SHH377964 from Creative biogene Category siRNA Species Reactivities Human

Human PLN siRNA - orb264091 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PLN shRNA Plasmid (Human) - CHH3589 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PLN miRNA 3'UTR clone - MiUTR3H-01737 from Creative biogene Species Reactivities Human

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