| Gene Symbol |
PLN
|
| Entrez Gene |
5350
|
| Alt Symbol |
CMD1P, CMH18, PLB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholamban
|
| Other Description |
cardiac phospholamban
|
| Swissprots |
P26678
|
| Accessions |
AAD55950 EAW48198 P26678 AK311799 BAG34742 BC005269 AAH05269 BP259965 DQ893034 ABM83960 DQ896146 ABM87145 M60411 AAA60109 M63603 AAA60083 NM_002667 NP_002658
|
| Function |
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}.
|
| Subcellular Location |
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Heart muscle (at protein level). {ECO:0000269|PubMed:17241641}.
|
| Top Pathways |
Calcium signaling pathway, Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, cAMP signaling pathway
|