| Gene Symbol |
MALT1
|
| Entrez Gene |
10892
|
| Alt Symbol |
IMD12, MLT, MLT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MALT1 paracaspase
|
| Other Description |
MALT lymphoma-associated translocation|MALT1 protease|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation gene 1|mucosa-associated lymphoid tissue lymphoma translocation protein 1|paracaspase
|
| Swissprots |
Q9UDY8 Q9ULX4 Q9NTB7
|
| Accessions |
EAW63078 EAW63079 Q9UDY8 AB026118 BAA83099 AF070528 AF130356 AAD38507 AF316597 AAG38589 AK024859 AK092004 AK291386 BAF84075 AL137399 CAB70725 BC030143 AAH30143 DQ892319 ABM83245 DQ895521 ABM86447 XM_011525794 XP_011524096 XR_935190 NM_006785 NP_006776 NM_173844 NP_776216
|
| Function |
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
|
| Tissue Specificity |
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
|
| Top Pathways |
T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis
|
![Western Blot: MALT1 Overexpression Lysate (Adult Normal) [NBL1-12832] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MALT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9483_MALT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12832-img0002.jpg)
![Western Blot: MALT1 Overexpression Lysate (Adult Normal) [NBP2-05067] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MALT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5055_MALT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05067-img0001.jpg)