MALT1

Gene Symbol	MALT1
Entrez Gene	10892
Alt Symbol	IMD12, MLT, MLT1
Species	Human
Gene Type	protein-coding
Description	MALT1 paracaspase
Other Description	MALT lymphoma-associated translocation|MALT1 protease|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation gene 1|mucosa-associated lymphoid tissue lymphoma translocation protein 1|paracaspase
Swissprots	Q9UDY8 Q9ULX4 Q9NTB7
Accessions	EAW63078 EAW63079 Q9UDY8 AB026118 BAA83099 AF070528 AF130356 AAD38507 AF316597 AAG38589 AK024859 AK092004 AK291386 BAF84075 AL137399 CAB70725 BC030143 AAH30143 DQ892319 ABM83245 DQ895521 ABM86447 XM_011525794 XP_011524096 XR_935190 NM_006785 NP_006776 NM_173844 NP_776216
Function	Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
Tissue Specificity	Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
Top Pathways	T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MALT1 - MBS1266055 from MyBioSource Species Human Accession BC030143

Human MALT1 cDNA clone(NM_173844.1) - CDFG011011 from Creative Biomart Species Human Accession NM_173844.1

Human MALT1 cDNA clone(NM_006785.2) - CDFH010925 from Creative Biomart Species Human Accession NM_006785.2

Human MALT1 ORF clone(NM_006785.2) - CDCL185242 from Creative Biomart Species Human Accession NM_006785.2

Human MALT1 ORF Clone(NM_006785.2) - CDCR293696 from Creative Biomart Species Human Accession NM_006785.2

Human MALT1 ORF Clone(NM_006785.2) - CDCR293697 from Creative Biomart Species Human Accession NM_006785.2

Human MALT1 ORF Clone(NM_006785.2) - CDCR293698 from Creative Biomart Species Human Accession NM_006785.2

Human MALT1 ORF Clone(NM_173844.1) - CDCR322351 from Creative Biomart Species Human Accession NM_173844.1

Human MALT1 ORF Clone(NM_173844.1) - CDCR322352 from Creative Biomart Species Human Accession NM_173844.1

Human MALT1 Gene ORF cDNA clone in cloning vector - HG11618-M from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid - HG11618-UT from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11618-NH from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11618-CH from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11618-CY from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11618-ANG from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11618-ACR from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11618-ANR from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11618-NF from Sino Biological Species Human

Human MALT1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11618-M-F from Sino Biological Species Human Accession NM_006785.2

Human MALT1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11618-CF from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11618-NM from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11618-ACG from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11618-CM from Sino Biological Species Human

Human MALT1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11618-NY from Sino Biological Species Human

Human MALT1 ORF clone(NM_006785.2) - CDCL185242 from Creative biogene Species Human

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