MALT1
| Gene Symbol | MALT1 |
|---|---|
| Entrez Gene | 10892 |
| Alt Symbol | IMD12, MLT, MLT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MALT1 paracaspase |
| Other Description | MALT lymphoma-associated translocation|MALT1 protease|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation gene 1|mucosa-associated lymphoid tissue lymphoma translocation protein 1|paracaspase |
| Swissprots | Q9UDY8 Q9ULX4 Q9NTB7 |
| Accessions | EAW63078 EAW63079 Q9UDY8 AB026118 BAA83099 AF070528 AF130356 AAD38507 AF316597 AAG38589 AK024859 AK092004 AK291386 BAF84075 AL137399 CAB70725 BC030143 AAH30143 DQ892319 ABM83245 DQ895521 ABM86447 XM_011525794 XP_011524096 XR_935190 NM_006785 NP_006776 NM_173844 NP_776216 |
| Function | Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}. |
| Subcellular Location | Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. |
| Tissue Specificity | Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. |
| Top Pathways | T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis |
MALT1 CRISPR/Cas9 KO Plasmid (h) - sc-400791 from Santa Cruz Biotechnology
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MALT1 HDR Plasmid (h) - sc-400791-HDR from Santa Cruz Biotechnology
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MALT1 Double Nickase Plasmid (h) - sc-400791-NIC from Santa Cruz Biotechnology
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MALT1 Double Nickase Plasmid (h2) - sc-400791-NIC-2 from Santa Cruz Biotechnology
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MALT1 CRISPR Activation Plasmid (h) - sc-400791-ACT from Santa Cruz Biotechnology
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MALT1 CRISPR Activation Plasmid (h2) - sc-400791-ACT-2 from Santa Cruz Biotechnology
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MALT1 Lentiviral Activation Particles (h) - sc-400791-LAC from Santa Cruz Biotechnology
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MALT1 Lentiviral Activation Particles (h2) - sc-400791-LAC-2 from Santa Cruz Biotechnology
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MALT1 siRNA (h) - sc-35845 from Santa Cruz Biotechnology
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MALT1 shRNA Plasmid (h) - sc-35845-SH from Santa Cruz Biotechnology
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MALT1 shRNA (h) Lentiviral Particles - sc-35845-V from Santa Cruz Biotechnology
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MALT1 RNAi - H00010892-R02 from Novus Biologicals
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MALT1 RNAi - H00010892-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12953 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12953 from Sigma-Aldrich
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MALT1 siRNA (Human) - CRH7422 from Cohesion Biosciences
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MALT1 CRISPR/Cas9 KO Plasmid (h2) - sc-400791-KO-2 from Santa Cruz Biotechnology
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MALT1 HDR Plasmid (h2) - sc-400791-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MALT1 (NM_173844.1) - SHH337151 from Creative biogene
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shRNA set against Human MALT1(NM_173844.1) - SHH172055 from Creative biogene
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shRNA set against Human MALT1(NM_006785.2) - SHH172073 from Creative biogene
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Human MALT1 siRNA - orb267924 from Biorbyt
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MALT1 shRNA Plasmid (Human) - CHH7422 from Cohesion Biosciences
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MALT1 miRNA 3'UTR clone - MiUTR1H-06028 from Creative biogene
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