MALT1

Gene Symbol MALT1
Entrez Gene 10892
Alt Symbol IMD12, MLT, MLT1
Species Human
Gene Type protein-coding
Description MALT1 paracaspase
Other Description MALT lymphoma-associated translocation|MALT1 protease|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation gene 1|mucosa-associated lymphoid tissue lymphoma translocation protein 1|paracaspase
Swissprots Q9UDY8 Q9ULX4 Q9NTB7
Accessions EAW63078 EAW63079 Q9UDY8 AB026118 BAA83099 AF070528 AF130356 AAD38507 AF316597 AAG38589 AK024859 AK092004 AK291386 BAF84075 AL137399 CAB70725 BC030143 AAH30143 DQ892319 ABM83245 DQ895521 ABM86447 XM_011525794 XP_011524096 XR_935190 NM_006785 NP_006776 NM_173844 NP_776216
Function Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. {ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
Tissue Specificity Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
Top Pathways T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis

MALT1 Antibody - 2494 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MALT1 Antibody.

MALT1 (C-16) - sc-20553 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MALT1 siRNA (h): sc-35845. Western blot analysis of MALT1 expression in non-transfected control (A) and MALT1 siRNA transfected (B) HeLa cells. Blot probed with MALT1 (C-16): sc-20553. α-actinin (H-2): sc-17829 used as specificity and loading control.

MALT1 (E-13) - sc-20552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MALT1 (E-13): sc-20552. Western blot analysis of MALT1 expression in Jurkat (A), Daudi (B), RAW 264.7 (C) and IB4 (D) whole cell lysates.

MALT1 (T-16) - sc-33952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MALT1 (H-300) - sc-28246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MALT1 (H-300): sc-28246. Immunofluorescence staining of normal mouse kidney frozen section showing cytoplasmic staining.

MALT1 (B-12) - sc-46677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MALT1 (B-12): sc-46677. Immunoperoxidase staining of formalin fixed, paraffin-embedded human malignant lymphoma showing membrane staining of tumor cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

MALT1 (K-20) - sc-33953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MALT1 (clone 50) - sc-130494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MALT1 (k100): sc-130494. Western blot analysis of MALT1 expression in Jurkat (A), Daudi (B), HeLa (C) and U68MG (D) whole cell lysates.

Anti-MALT1 antibody - ab97334 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-MALT1 antibody (ab97334) at 1/10000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-MALT1 antibody - ab93661 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab93661, at a 1/100 dilution, staining MALT1 in formalin fixed, paraffin embedded Human lymphoma tissue by Immunohistochemistry.

Anti-MALT1 antibody - ab115030 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MALT1 antibody (ab115030) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-MALT1 antibody - ab168955 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-MALT1 antibody (ab168955) at 1/500 dilutionLane 1 : MALT1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-MALT1 antibody - ab22103 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MALT1 antibody (ab22103) at 0.5 µg/ml + Jurkat cells lysateObserved band size : 68 kDa (why is the actual band size different from the predicted?)Additional bands at : 116 kDa,35 kDa,38 kDa,50 kDa,96 kDa. We are unsure as to the identity of these extra bands.

Anti-MALT1 antibody [EP603Y] - ab33921 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP603Y
Overlay histogram showing Jurkat cells stained with ab33921 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab33921, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in Jurkat cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-MALT1 antibody [EPR604] - ab109724 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR604
All lanes : Anti-MALT1 antibody [EPR604] (ab109724) at 1/1000 dilutionLane 1 : Jurkat lysateLane 2 : K562 lysateLane 3 : Bone marrow lysateLane 4 : PBMC lysatesLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MALT1 antibody [MT1/410] - ab178581 from Abcam

Prices $376.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone MT1/410
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MALT1 with ab178581 at 1/200 dilution followed by peroxidase-conjugate and DAB chromogen.

Anti-MALT1 Antibody (aa43-57) IHC-plus™ - LS-B2051 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MALT1 antibody IHC of human colon-lymphoid follicle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2051 concentration 10 ug/ml.

Anti-MALT1 Antibody (C-Terminus) - LS-C336256 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of MALT1 in human spleen tissue with MALT1 antibody at 5 ug/mL.

Anti-MALT1 Antibody (clone 50) IHC-plus™ - LS-B3791 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 50
Anti-MALT1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3791 concentration 20 ug/ml.

Anti-MALT1 Antibody (C-Terminus) - LS-C37280 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MALT1 Antibody (aa701-808) - LS-C121248 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MALT1 Antibody - LS-C125906 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MALT1 Antibody (N-Terminus, clone EP603Y) - LS-C49633 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP603Y
Western blot analysis on Jurkat cell lysate using anti-MALT1 (N-term) antibody, dilution 1:2000.

Anti-MALT1 Antibody (clone MT1/410) - LS-C191700 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MT1/410
Immunohistochemistry of formalin-fixed, paraffin-embedded human tonsil stained with MALT1 MT1/410 antibody (1:200), peroxidase-conjugate and DAB chromogen.

Anti-MALT1 Antibody (Internal, clone EPR604) - LS-C138123 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR604
Western blot analysis on (A) Jurkat, (B) K562, (C) bone marrow, and (D) PBMC lysates using anti-MALT1 / MLT1 antibody.
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