GM2A

Gene Symbol GM2A
Entrez Gene 2760
Alt Symbol GM2-AP, SAP-3
Species Human
Gene Type protein-coding
Description GM2 ganglioside activator
Other Description cerebroside sulfate activator protein|ganglioside GM2 activator|shingolipid activator protein 3|sphingolipid activator protein 3
Swissprots D3DQH6 Q14428 Q14426 Q6LBL5 B2R699 P17900
Accessions AAD25741 AAF63788 EAW61680 EAW61681 P17900 AK225978 AK298867 BAG60987 AK312494 BAG35396 BC009273 AAH09273 BM834780 BX473154 DQ891914 ABM82840 DQ895098 ABM86024 L01439 AAA52767 M76477 AAA35907 X16087 CAA34215 X61094 CAA43407 X61095 CAA43408 X62078 CAA43993 NM_000405 NP_000396 NM_001167607 NP_001161079
Function The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. {ECO:0000250}.
Subcellular Location Lysosome.
Top Pathways Lysosome

GM2-AP (E-7) - sc-514437 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GM2-AP (E-7): sc-514437. Western blot analysis of GM2-AP expression in JAR whole cell lysate.

GM2-AP (F-14) - sc-68088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GM2-AP (P-12) - sc-68089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GM2A antibody - ab113416 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Lane 1 : Anti-GM2A antibody (ab113416) at 1 µg/mlLane 2 : Anti-GM2A antibody (ab113416) at 1 mg/mlLane 1 : HEK293 lysate overexpressing Human GM2A Lane 2 : Mock-transfected HEK293 Lysates/proteins at 10 µg per lane.

Anti-GM2A antibody - ab107501 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GM2A antibody (ab107501) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-GM2A antibody - ab113440 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-GM2A antibody (ab113440) at 0.300000011921 µg/ml + Rat kidney lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-GM2A antibody - ab150476 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.

Anti-GM2A antibody - ab118433 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118433 at 12.5µg/ml staining GM2A in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.

Anti-GM2A antibody - ab118450 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118450 at a concentration of 12.5 µg/ml.

Anti-GM2A antibody - ab118453 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118453, at 7.5 µg/ml, staining GM2A in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.

Anti-GM2A antibody - ab67076 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-GM2A antibody (ab67076) at 1/500 dilutionLane 1 : GM2A transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg/ml per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-GM2A antibody - ab104323 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GM2A antibody (ab104323) at 1 µg/ml + HeLa cell lysate at 10 µg

Anti-GM2A Antibody (aa164-175) - LS-C139706 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GM2A Antibody (aa179-189) - LS-C139707 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GM2A Antibody (HRP) - LS-C183195 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (FITC) - LS-C183196 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody - LS-C189990 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (N-Terminus) - LS-C111076 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GM2A antibody LS-C111076 Western blot of HT1080 cell lysate.

Anti-GM2A Antibody (HRP) - LS-C212101 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (aa35-84) - LS-C116318 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GM2A antibody LS-C116318 Western blot of HeLa lysate.

Anti-GM2A Antibody - LS-C212102 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (FITC) - LS-C212104 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (Biotin) - LS-C212105 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (aa25-54, AP) - LS-C214754 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GM2A Antibody (aa25-54, APC) - LS-C214755 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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