GM2A

Gene Symbol	GM2A
Entrez Gene	2760
Alt Symbol	GM2-AP, SAP-3
Species	Human
Gene Type	protein-coding
Description	GM2 ganglioside activator
Other Description	cerebroside sulfate activator protein|ganglioside GM2 activator|shingolipid activator protein 3|sphingolipid activator protein 3
Swissprots	D3DQH6 Q14428 Q14426 Q6LBL5 B2R699 P17900
Accessions	AAD25741 AAF63788 EAW61680 EAW61681 P17900 AK225978 AK298867 BAG60987 AK312494 BAG35396 BC009273 AAH09273 BM834780 BX473154 DQ891914 ABM82840 DQ895098 ABM86024 L01439 AAA52767 M76477 AAA35907 X16087 CAA34215 X61094 CAA43407 X61095 CAA43408 X62078 CAA43993 NM_000405 NP_000396 NM_001167607 NP_001161079
Function	The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. {ECO:0000250}.
Subcellular Location	Lysosome.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GM2A-Over-expression-Lysate - LY12580a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GM2A 293T Cell Transient Overexpression Lysate(Denatured) - H00002760-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GM2A 293T Cell Transient Overexpression Lysate(Denatured) - H00002760-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GM2A 293 Cell Lysate - 400224 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

GM2A Overexpression Lysate (Denatured) - H00002760-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

GM2A Overexpression Lysate (Native) - NBL1-11135 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GM2A Over-expression Lysate Product - GWB-13E772 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human GM2A Insect Cell Lysate (WB positive control) - 13246-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human GM2A Baculovirus-Insect Cells Transfected Lysate Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175162 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

GM2A Overexpression Lysate (Denatured) - H00002760-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human GM2A Knockdown Stable Cell Line - CSC-DC006362 from Creative biogene Category Cell Line Species Human

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