GM2A

Gene Symbol GM2A
Entrez Gene 2760
Alt Symbol GM2-AP, SAP-3
Species Human
Gene Type protein-coding
Description GM2 ganglioside activator
Other Description cerebroside sulfate activator protein|ganglioside GM2 activator|shingolipid activator protein 3|sphingolipid activator protein 3
Swissprots D3DQH6 Q14428 Q14426 Q6LBL5 B2R699 P17900
Accessions AAD25741 AAF63788 EAW61680 EAW61681 P17900 AK225978 AK298867 BAG60987 AK312494 BAG35396 BC009273 AAH09273 BM834780 BX473154 DQ891914 ABM82840 DQ895098 ABM86024 L01439 AAA52767 M76477 AAA35907 X16087 CAA34215 X61094 CAA43407 X61095 CAA43408 X62078 CAA43993 NM_000405 NP_000396 NM_001167607 NP_001161079
Function The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. {ECO:0000250}.
Subcellular Location Lysosome.
Top Pathways Lysosome

GM2-AP CRISPR/Cas9 KO Plasmid (h) - sc-408130 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP HDR Plasmid (h) - sc-408130-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP Double Nickase Plasmid (h) - sc-408130-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP Double Nickase Plasmid (h2) - sc-408130-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP CRISPR Activation Plasmid (h) - sc-408130-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP CRISPR Activation Plasmid (h2) - sc-408130-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP Lentiviral Activation Particles (h) - sc-408130-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP Lentiviral Activation Particles (h2) - sc-408130-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GM2-AP siRNA (h) - sc-62385 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GM2-AP shRNA Plasmid (h) - sc-62385-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GM2-AP shRNA (h) Lentiviral Particles - sc-62385-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GM2A RNAi - H00002760-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU030201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9384 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9384 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GM2A siRNA (Human) - CRH1833 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GM2A - MBS8204710 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GM2A (NM_000405.4) - SHH303242 from Creative biogene

Category siRNA
Species Reactivities Human

GM2A shRNA Plasmid (Human) - CHH1833 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GM2A miRNA 3'UTR clone - MiUTR4H-TG03871 from Creative biogene

Species Reactivities Human
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